{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:27:15Z","timestamp":1786321635551,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81500650"],"award-info":[{"award-number":["NSFC 81500650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["1501219107"],"award-info":[{"award-number":["1501219107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["NSFC 81500650"],"award-info":[{"award-number":["NSFC 81500650"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["1501219107"],"award-info":[{"award-number":["1501219107"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with <jats:italic>Acanthosis nigricans<\/jats:italic> (AN) and related metabolic indices in obese patients. <jats:italic>Methods.<\/jats:italic> A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180\u2009min. <jats:italic>Results.<\/jats:italic> AN group had higher serum UA levels than OB group. Circulating UA levels were associated with BMI, dyslipidemia, hypertension, IR, and AN. In logistic regression analyses (multivariable\u2010adjusted), a high serum UA level was associated with high odds ratios (ORs) (95% confidence interval [CI]) for AN in females (ORs\u2009=\u20093.00 and 95% CI [1.02\u20138.84]) and males (ORs\u2009=\u20096.07 and 95% CI [2.16\u201317.06]) in the highest quartile (Q4) of serum UA. <jats:italic>Conclusions.<\/jats:italic> Serum UA levels were positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, hyperlipidemia, and AN and may be an important risk factor in the development of AN; further evidences in vitro and in vivo are needed to investigate the direct or indirect relationship.<\/jats:p>","DOI":"10.1155\/2017\/5438157","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T21:01:14Z","timestamp":1488920474000},"page":"1-9","source":"Crossref","is-referenced-by-count":29,"title":["The Associations of Serum Uric Acid with Obesity-Related <i>Acanthosis nigricans<\/i> and Related Metabolic Indices"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-3558","authenticated-orcid":true,"given":"Cuiling","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-3140","authenticated-orcid":true,"given":"Ran","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-1181","authenticated-orcid":true,"given":"Mingming","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Biomedical Sciences, University of Georgia College of Pharmacy, Athens, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharvan","family":"Rampersad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"You","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjun","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-3224","authenticated-orcid":true,"given":"Hui","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-7070","authenticated-orcid":true,"given":"Shen","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"113","key":"1","first-page":"693","volume":"19","year":"2005","journal-title":"Polski Merkuriusz Lekarski"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-4-9"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/art.30520"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000248752.08807.4c"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1276"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.11.014"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2010.507218"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70320-X"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/754678"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-1933-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700203"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1177\/10598405070230050201"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.016"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.10.1655"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.84.11.1839"},{"issue":"2","key":"16","first-page":"26","volume":"17","year":"1992","journal-title":"The Nurse Practitioner"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1658062"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1373\/49.4.644"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-419"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.14.028"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.10.006"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2005.tb00132.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00140.2005"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00600.2006"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.032"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0800885"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30275-7"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109826"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30175-1"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.04.080"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-016-0265-8"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0386-2"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2017\/5438157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2017\/5438157.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2017\/5438157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T17:28:25Z","timestamp":1589736505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2017\/5438157\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":32,"alternative-id":["5438157","5438157"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5438157","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}