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The behaviors include tonic and phasic spiking, tonic and phasic bursting, class 1 and class 2 excitability, rebound spike, rebound burst, subthreshold oscillation, and accommodated spiking along with inhibition neuron responses. Here, we investigate the neuronal spiking patterns in Parkinson\u2019s disease through our proposed model. Abnormal pattern of subthalamic nucleus in Parkinson\u2019s disease can be studied through variations in the shape and frequency of firing patterns. Our proposed model introduces mathematical equations, where these patterns can be derived and clearly differentiated from one another. The irregular and arrhythmic behaviors of subthalamic nucleus firing pattern under normal conditions can easily be transformed to those caused by Parkinson\u2019s disease through simple parameter modifications in the proposed model. This model can explicitly show the change of neuronal activity patterns in Parkinson\u2019s disease, which may eventually lead to effective treatment with deep brain stimulation devices.<\/jats:p>","DOI":"10.1155\/2017\/5472752","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:54:25Z","timestamp":1504720465000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Hyperbolic Modeling of Subthalamic Nucleus Cells to Investigate the Effect of Dopamine Depletion"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-5535","authenticated-orcid":true,"given":"Mohammad","family":"Daneshzand","sequence":"first","affiliation":[{"name":"Department of Computer Science and Engineering, University of Bridgeport, Bridgeport, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miad","family":"Faezipour","sequence":"additional","affiliation":[{"name":"Department of Computer Science and 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