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Interleukin- (IL-) 22 is considered a proinflammatory cytokine. Recent evidence has demonstrated that it plays a role in cardiovascular diseases. In the recent study, we investigate whether IL-22 is involved in cardiac hypertrophy. <jats:italic>Methods<\/jats:italic>. Angiotensin II was used to build hypertrophy model and the IL-22 and IL-22 receptor 1 (IL-22R1) levels in heart tissue were measured. In addition, angiotensin II-treated mice received an injection of anti-IL-22-neutralizing antibody (nAb) to investigate the effects of IL-22 nAb on myocardial hypertrophy, cardiac function, and cardiac fibrosis; the activation of the signaling pathway and the prohypertrophic inflammatory cytokine mRNA levels was detected. Furthermore, the effect of IL-22 nAb on angiotensin II-induced hypertrophy in vitro was also determined. <jats:italic>Results<\/jats:italic>. IL-22 and IL-22R1 levels were significantly increased after angiotensin II infusion. Anti-IL-22 nAb significantly alleviated the severity of hypertrophy, prevented systolic and diastolic abnormalities, reduced cardiac fibrosis, STAT3 and ERK phosphorylation, and downregulated the mRNA expression of IL-17, IL-6, IL-1<jats:italic>\u03b2<\/jats:italic>, IFN-<jats:italic>\u03b3<\/jats:italic>, and TNF-<jats:italic>\u03b1<\/jats:italic>. In addition, IL-22 nAb attenuated angiotensin II-induced hypertrophy in H9C2 cells. <jats:italic>Conclusion<\/jats:italic>. Our data demonstrated that neutralization of IL-22 alleviated angiotensin II-induced cardiac hypertrophy. The downregulation of IL-22 may be a novel therapeutic strategy to prevent cardiac hypertrophy.<\/jats:p>","DOI":"10.1155\/2017\/5635929","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T18:31:16Z","timestamp":1511375476000},"page":"1-10","source":"Crossref","is-referenced-by-count":24,"title":["Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jing","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Cardiology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China"},{"name":"Department of Cardiology, Hubei Key Laboratory of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Wuhan 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of 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