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The experimental liver injury was induced by 2\u2010acetylaminofluorene (2\u2010AAF) treatment combined with partial hepatectomy (PH). EZP treated 2\u2010AAF\/PH\u2010induced liver injury by the therapeutic and prophylactic administration. After the administration of EZP, the activities of aspartic transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and gamma\u2010glutamyl transpeptidase (<jats:italic>\u03b3<\/jats:italic>\u2010GT) were decreased, followed by the decreased levels of hepatocyte apoptosis and caspase\u20103 expression. However, the secretion of albumin, liver weight, and index of liver weight were elevated. Microscopic examination showed that EZP restored pathological liver injury. Meanwhile, Rheb and mammalian target of rapamycin (mTOR) activation were suppressed, and tuberous sclerosis complex (TSC) expression was elevated in liver tissues induced by 2\u2010AAF\/PHx and accompanied with lower\u2010expression of Bax, Notch1, p70S6K, and 4E\u2010EIF and upregulated levels of Bcl\u20102 and Cyclin D. Hepatoprotective effect of EZP was possibly realized via inhibiting TSC\/mTOR signaling pathway to suppress excessive apoptosis of hepatocyte.<\/jats:p>","DOI":"10.1155\/2017\/5653643","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T21:07:01Z","timestamp":1496178421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Erzhi Pill\u00ae Repairs Experimental Liver Injury via TSC\/mTOR Signaling Pathway Inhibiting Excessive 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