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The study was designed to explore whether hydrogen sulphide (H<jats:sub>2<\/jats:sub>S) and nitric oxide (NO) generation changed in D\u2010galactose\u2010 (D\u2010gal\u2010) induced ageing, the possible effects of exogenous H<jats:sub>2<\/jats:sub>S supplementation, and related mechanisms. <jats:italic>Results<\/jats:italic>. In D\u2010gal\u2010induced senescent mice, both H<jats:sub>2<\/jats:sub>S and NO levels in the heart, liver, and kidney tissues were decreased significantly. A similar trend was observed in D\u2010gal\u2010challenged human umbilical vein endothelial cells (HUVECs). Sustained H<jats:sub>2<\/jats:sub>S donor (NaHS) treatment for 2 months elevated H<jats:sub>2<\/jats:sub>S and NO levels in these mice, and during this period, the D\u2010gal\u2010induced senescent phenotype was reversed. The protective effect of NaHS is associated with a decrease in reactive oxygen species levels and an increase in antioxidants, such as glutathione, and superoxide dismutase and glutathione peroxidase activities. Increased expression of the H<jats:sub>2<\/jats:sub>S\u2010producing enzymes cystathionine <jats:italic>\u03b3<\/jats:italic>\u2010lyase (CSE) and cystathionine\u2010<jats:italic>\u03b2<\/jats:italic>\u2010synthase (CBS) in the heart, liver, and kidney tissues was observed in the NaHS\u2010treated groups. NaHS supplementation also significantly postponed D\u2010gal\u2010induced HUVEC senescence. <jats:italic>Conclusions<\/jats:italic>. Endogenous hydrogen sulphide production in both ageing mice and endothelial cells is insufficient. Exogenous H<jats:sub>2<\/jats:sub>S can partially rescue ageing\u2010related dysfunction by inducing endogenous H<jats:sub>2<\/jats:sub>S and NO production and reducing oxidative stress. Restoring endogenous H<jats:sub>2<\/jats:sub>S production may contribute to healthy ageing, and H<jats:sub>2<\/jats:sub>S may have antiageing effects.<\/jats:p>","DOI":"10.1155\/2017\/5707830","type":"journal-article","created":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T21:01:06Z","timestamp":1492981266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["H<sub>2<\/sub>S Donor NaHS Changes the Production of Endogenous H<sub>2<\/sub>S and NO in D\u2010Galactose\u2010Induced Accelerated Ageing"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-9437","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Lan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Pan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-2957","authenticated-orcid":false,"given":"Yi-Chun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-348X","authenticated-orcid":false,"given":"Ming-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-4248","authenticated-orcid":false,"given":"Qian-Zhou","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,23]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68833"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61719-X"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18144-8_14"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.024"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/15476910903510806"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.07.004"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.2830"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.03.007"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.12.010"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.12.003"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708580200"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4645"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5604"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu299"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710191104"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524727113"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-017-8188-6"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009-3419.2017.03.05"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.01.025"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12900"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejop.2016.10.002"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/c6cc10114c"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13450"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.55"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061235"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.001"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.05.006"},{"key":"e_1_2_9_28_2","first-page":"276","article-title":"Exogenous hydrogen sulfide reduces vascular aging in D-galactose-induced subacute aging rats","volume":"66","author":"Qiao W. 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