{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:21Z","timestamp":1787017701201,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"\n Purpose<\/jats:italic>\n . To report the visual, refractive, and corneal topography and wavefront aberration results of accelerated corneal cross-linking (CXL) during a 24-month follow-up.\n Methods<\/jats:italic>\n . Forty-seven eyes underwent riboflavin-ultraviolet A-induced accelerated CXL treatment (30\u2009mW\/cm\n 2<\/jats:sup>\n with a total dose of 7.2\u2009joules\/cm\n 2<\/jats:sup>\n ). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical and cylindrical values, keratometry (\n \n \n K<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n ) measurements (\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n s<\/mml:mi>\n t<\/mml:mi>\n e<\/mml:mi>\n e<\/mml:mi>\n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n ,\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n f<\/mml:mi>\n l<\/mml:mi>\n a<\/mml:mi>\n t<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n ,\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n a<\/mml:mi>\n v<\/mml:mi>\n g<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n , and\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n a<\/mml:mi>\n p<\/mml:mi>\n e<\/mml:mi>\n x<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n ), central corneal thickness, and anterior corneal aberrometric analyses including total wavefront error (WFE), total high order aberration (HOA), astigmatism, trefoil, coma, quadrafoil, secondary astigmatism, and spherical aberration were evaluated.\n Results<\/jats:italic>\n . The mean UDVA and CDVA were significantly improved at 1 (\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.003<\/mml:mn>\n <\/mml:math>\n and\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.004<\/mml:mn>\n <\/mml:math>\n , resp.) and 2 years after treatment (\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n and\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n , resp.). The mean\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n s<\/mml:mi>\n t<\/mml:mi>\n e<\/mml:mi>\n e<\/mml:mi>\n p<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n ,\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n f<\/mml:mi>\n l<\/mml:mi>\n a<\/mml:mi>\n t<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n ,\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n a<\/mml:mi>\n v<\/mml:mi>\n e<\/mml:mi>\n r<\/mml:mi>\n a<\/mml:mi>\n g<\/mml:mi>\n e<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n , and\n \n \n \n \n K<\/mml:mi>\n <\/mml:mrow>\n \n a<\/mml:mi>\n p<\/mml:mi>\n e<\/mml:mi>\n x<\/mml:mi>\n <\/mml:mrow>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math>\n values were significantly lower than baseline at 12 months (\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.008<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.024<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n , and\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.014<\/mml:mn>\n <\/mml:math>\n , resp.) and 24 months (\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.014<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.017<\/mml:mn>\n <\/mml:math>\n ,\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n , and\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.012<\/mml:mn>\n <\/mml:math>\n , resp.). Corneal thickness showed a significant decrease at 1 month. Total HOA and coma decreased significantly at the 12-month (\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n and\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.009<\/mml:mn>\n <\/mml:math>\n , resp.) and 24-month visits (\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n and\n \n p<\/mml:mi>\n =<\/mml:mo>\n 0.007<\/mml:mn>\n <\/mml:math>\n , resp.).\n Conclusion<\/jats:italic>\n . Accelerated CXL (30\u2009mW\/cm\n 2<\/jats:sup>\n ) was found to be effective in improving UDVA, CDVA, corneal topography readings, total HOA, and coma aberrations during the 24-month follow-up.\n <\/jats:p>","DOI":"10.1155\/2017\/5714372","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T16:07:48Z","timestamp":1484755668000},"page":"1-6","source":"Crossref","is-referenced-by-count":18,"title":["Refractive, Topographic, and Aberrometric Results at 2-Year Follow-Up for Accelerated Corneal Cross-Link for Progressive Keratoconus"],"prefix":"10.1155","volume":"2017","author":[{"given":"Erc\u00fcment","family":"Bozkurt","sequence":"first","affiliation":[{"name":"Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-148X","authenticated-orcid":true,"given":"Engin 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Karaaga\u00e7","family":"G\u00fcnaydin","sequence":"additional","affiliation":[{"name":"Beyoglu Eye Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Demirok","sequence":"additional","affiliation":[{"name":"Istanbul Medeniyet University Medical School, Department of Ophthalmology, Istanbul, 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