{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:04:24Z","timestamp":1771941864165,"version":"3.50.1"},"reference-count":116,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Angiogenesis has been shown to be a potential therapeutic target for early stages of diabetic nephropathy in a number of animal experiments. Vascular endothelial growth factor (VEGF) is the main mediator for abnormal angiogenesis in diabetic glomeruli. Although beneficial effects of anti-VEGF antibodies have previously been demonstrated in diabetic animal experiments, recent basic and clinical evidence has revealed that the blockade of VEGF signaling resulted in proteinuria and renal thrombotic microangiopathy, suggesting the importance of maintaining normal levels of VEGF in the kidneys. Therefore, antiangiogenic therapy for diabetic nephropathy should eliminate excessive glomerular angiogenic response without accelerating endothelial injury. Some endogenous antiangiogenic factors such as endostatin and tumstatin inhibit overactivation of endothelial cells but do not specifically block VEGF signaling. In addition, the novel endothelium-derived antiangiogenic factor vasohibin-1 enhances stress tolerance and survival of the endothelial cells, while inhibiting excess angiogenesis. These factors have been demonstrated to suppress albuminuria and glomerular alterations in a diabetic mouse model. Thus, antiangiogenic therapy with promising candidates will possibly improve renal prognosis in patients with early stages of diabetic nephropathy.<\/jats:p>","DOI":"10.1155\/2017\/5724069","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T21:02:31Z","timestamp":1501621351000},"page":"1-12","source":"Crossref","is-referenced-by-count":57,"title":["Antiangiogenic Therapy for Diabetic Nephropathy"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-5892","authenticated-orcid":true,"given":"Katsuyuki","family":"Tanabe","sequence":"first","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-7553","authenticated-orcid":true,"given":"Yasufumi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-5170","authenticated-orcid":true,"given":"Jun","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0195-27"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911423031"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/380439a0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1126\/science.2479986"},{"issue":"2, part 2","key":"6","doi-asserted-by":"crossref","first-page":"H687","DOI":"10.1152\/ajpcell.1997.273.2.C687","volume":"273","year":"1997","journal-title":"American Journal of Physiology"},{"issue":"8","key":"7","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","volume":"87","year":"1996","journal-title":"Blood"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1210\/mend-5-12-1806"},{"issue":"18","key":"9","first-page":"11946","volume":"266","year":"1991","journal-title":"Journal of Biological Chemistry"},{"issue":"14","key":"10","first-page":"4123","volume":"62","year":"2002","journal-title":"Cancer Research"},{"issue":"2","key":"11","first-page":"213","volume":"7","year":"1996","journal-title":"Cell Growth and Differentiation"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.12.6729"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.11.2768"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202527"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30336"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81402-6"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6577"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6254-9"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703554200"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.4161\/cam.5.4.17287"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.20.13390"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-6632(87)80069-7"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.09.020"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000294"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s004280000311"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/BF01614771"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399948"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2005.00492.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.11.2229"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07504.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00067.x"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-106295"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1925424"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07717.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.12.028"},{"issue":"5","key":"36","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1681\/ASN.V75661","volume":"7","year":"1996","journal-title":"Journal of the American Society of Nephrology"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6740"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000141038.28733.F2"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.441"},{"issue":"2, part 2","key":"40","first-page":"F240","volume":"268","year":"1995","journal-title":"American Journal of Physiology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc080770"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317423"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010075"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707330"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.64"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-2034-z"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1655"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.024"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00495.2006"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/184539"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050459"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070798"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011121170"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094540"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013070752"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00596.2011"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1159\/000177614"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2014040350"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2377-y"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.01.004"},{"issue":"5","key":"60","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.V125993","volume":"12","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.10.3090"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2006010064"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.11.039"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm311"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160481"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86418"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1159\/000365156"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116527"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0647"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00377.2009"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012121218"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300012200"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00820.x"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009060617"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4296"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001956200"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00133-8"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065298"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.7.1831"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81848-6"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.16.4414"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730882100"},{"issue":"5","key":"84","first-page":"890","volume":"29","year":"2002","journal-title":"Journal of Rheumatology"},{"issue":"8","key":"85","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1096\/fj.02-0824fje","volume":"17","year":"2003","journal-title":"The FASEB Journal"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002040"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.2891"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2016.03.006"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90200-3"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005020217"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90430.2008"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1038\/nm1696"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182166b6b"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S117007"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-248"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421152"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.01.185"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.067538"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080788"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2015.3193"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.03.007"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046459"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0073"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.169"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.10.028"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096932"},{"issue":"4","key":"107","first-page":"219","volume":"68","year":"2014","journal-title":"Acta Medica Okayama"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.04.176"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058580"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.02.022"},{"issue":"6","key":"111","first-page":"349","volume":"63","year":"2009","journal-title":"Acta Medica Okayama"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1790"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00503.2010"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107934"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12054"},{"key":"116","doi-asserted-by":"publisher","DOI":"10.5551\/jat.28902"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/5724069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/5724069.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/5724069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T18:20:52Z","timestamp":1659291652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/5724069\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":116,"alternative-id":["5724069","5724069"],"URL":"https:\/\/doi.org\/10.1155\/2017\/5724069","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}