{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:15:25Z","timestamp":1764782125189,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>This study evaluated the effect of menopausal hormone therapy (MHT) on serum concentration of copper in postmenopausal women depending on passive or active exposure to tobacco smoke or lack thereof. The study included healthy postmenopausal women aged 42\u201369 years, who used (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">76<\/mml:mn><\/mml:math>) or did not use (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">76<\/mml:mn><\/mml:math>) MHT. Salivary cotinine and serum copper concentrations were determined in all the study subjects. Salivary cotinine exceeded 14\u2009ng\/ml in 14 women from the MHT group (18.5%) and in 16 controls (21.1%). Up to 41 (27%) study subjects had serum copper above the upper normal limit (1.17\u2009mg\/l). No correlation was found between salivary cotinine and serum copper in women with cotinine concentrations &lt;14\u2009ng\/ml, and these two parameters correlated weakly in subjects with cotinine &gt;14\u2009ng\/ml. Salivary concentration of cotinine increased with serum copper level in the MHT group, but not in the controls; smokers using MHT presented with significantly higher serum copper than nonsmokers. These findings imply that MHT does not affect serum concentration of copper in women who are not exposed to tobacco smoke. However, MHT seems to contribute to unfavorable increase in serum copper in passive and active smokers.<\/jats:p>","DOI":"10.1155\/2017\/5732380","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T17:02:35Z","timestamp":1502730155000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["The Influence of Cigarette Smoke Exposure on the Copper Concentration in the Serum Depending on the Use of Menopausal Hormone Therapy"],"prefix":"10.1155","volume":"2017","author":[{"given":"Maria","family":"Jasi\u0144ska-Starczewska","sequence":"first","affiliation":[{"name":"Department of Public Health, Pomeranian Medical University in Szczecin, 48 \u017bo\u0142nierska Str., 71-210 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Szyd\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, 2 Siedlecka Str., 72-010 Police, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Mroczek","sequence":"additional","affiliation":[{"name":"Department of Humanities in Medicine, Pomeranian Medical University in Szczecin, 11 Ch\u0142apowskiego Str., 70-103 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Laszczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 48 \u017bo\u0142nierska Str., 71-210 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-4395","authenticated-orcid":true,"given":"Dariusz","family":"Chlubek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, 72 Powsta\u0144c\u00f3w Wlkp. 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