{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T21:58:14Z","timestamp":1765231094988,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>A 48-year-old man was diagnosed with multiple myeloma (IgG-k) and was treated with high-dose dexamethasone as an induction therapy followed by thalidomide-based regimens. Approximately 22 months after the initial diagnosis, the patient developed secondary plasma cell leukemia (PCL) with a white blood cell (WBC) count of 20.2\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L including 79.5% plasma cells. A G-banding chromosomal analysis in the bone marrow showed an t(11;14) abnormality of up to 5%, which was not detected at initial diagnosis. We immediately started bortezomib and dexamethasone therapy, but in just 7 days, the WBC count elevated to 48.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, and approximately 95% of them were medium-sized atypical lymphoid cells with multilobated nuclei. Although we subsequently initiated alternative regimens, the patient\u2019s condition deteriorated, and he died 4 months after developing PCL. Approximately 2 months before his death, the diameter of myeloma cells in the bone marrow enlarged by approximately twofold, and pleomorphic nuclei were present, indicating an anaplastic myeloma transformation. Concurrently, a 100% increase of the t(11;14) clone frequency was observed in the G-banding-analyzed bone marrow cells. Morphological transformation of myeloma cells into multilobated plasma cell nuclei can be considered as the starting point of the sequential process leading to anaplastic myeloma.<\/jats:p>","DOI":"10.1155\/2017\/5758368","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T18:50:18Z","timestamp":1513882218000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Morphological Transformation of Myeloma Cells into Multilobated Plasma Cell Nuclei within 7 Days in a Case of Secondary Plasma Cell Leukemia That Finally Transformed as Anaplastic Myeloma"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-644X","authenticated-orcid":true,"given":"Akihito","family":"Fujimi","sequence":"first","affiliation":[{"name":"Department of Hematology, Sapporo Kiyota Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nagamachi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sapporo Kiyota Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naofumi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sapporo Kiyota Hospital, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kanisawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Oji General Hospital, Tomakomai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830101)51:1<166::aid-cncr2820510132>3.0.co;2-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3109\/07357909009012059"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-731844"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/58.2.159"},{"issue":"3","key":"5","first-page":"438","volume":"49","year":"2006","journal-title":"Indian Journal of Pathology and Microbiology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.5.657"},{"issue":"5","key":"7","first-page":"385","volume":"34","year":"1992","journal-title":"Nouvelle Revue Fran\u00e7aise D\u2019H\u00e9matologie"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/bf01697984"},{"issue":"5","key":"9","first-page":"287","volume":"55","year":"1988","journal-title":"Virchows Archiv. 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