{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:42:28Z","timestamp":1783723348190,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Municipal Health and Family Planning Commission for Distinguished Young Doctors","award":["20141032"],"award-info":[{"award-number":["20141032"]}]},{"name":"Shanghai Municipal Health and Family Planning Commission for Distinguished Young Doctors","award":["81301571"],"award-info":[{"award-number":["81301571"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20141032"],"award-info":[{"award-number":["20141032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301571"],"award-info":[{"award-number":["81301571"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Wear particle-induced chronic inflammation and osteoclastogenesis are two critical factors in the osteolytic process. Curcumin (CUR) is an active compound of the medicinal herb <jats:italic>Curcuma longa<\/jats:italic> and has anti-inflammatory and antiosteoclastogenic properties. Our study tested the hypothesis that CUR might attenuate polymethylmethacrylate- (PMMA-) induced inflammatory osteolysis using mouse calvaria osteolysis model in vivo and in vitro. The mice were divided into four groups: phosphate-buffered saline group, CUR, PMMA, and PMMA\u2009+\u2009CUR groups. Three days before PMMA particle implantation, the mice were intraperitoneally injected with CUR (25\u2009mg\/kg\/day). Ten days after the operation, the mouse calvaria was harvested for microcomputed tomography, histomorphometry, and molecular biology analysis. As expected, CUR markedly reduced the secretion of tumor necrosis factor-<jats:italic>\u03b1<\/jats:italic>, interleukin- (IL-) 1<jats:italic>\u03b2<\/jats:italic>, and IL-6 in the calvarial organ culture. Moreover, CUR suppressed osteoclastogenesis and decreased bone resorption in vivo compared with PMMA-stimulated calvaria. Furthermore, CUR downregulated the osteoclast-specific gene expression and reversed the receptor activator of nuclear factor kappa-B ligand (RANKL)\/osteoprotegerin messenger RNA and protein ratio in PMMA particle-stimulated mice. These results suggest that CUR attenuated PMMA particle-induced inflammatory osteolysis by suppressing the RANKL signaling pathway in the murine calvarium, which could be a candidate compound to prevent and treat AL.<\/jats:p>","DOI":"10.1155\/2017\/5784374","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T17:01:49Z","timestamp":1505926909000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-0020","authenticated-orcid":true,"given":"Tao","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital, Shanghai, 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