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However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ and SGZ. This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery. Thus, enhancing the endogenous neurogenesis driven by ischemia and promoting the survival of newborn neurons can be promising therapeutic interventions for stroke. Here, we present an overview of the process of adult neurogenesis and the potential of stroke-induced neurogenesis on brain repair.<\/jats:p>","DOI":"10.1155\/2017\/5868632","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T17:04:43Z","timestamp":1500570283000},"page":"1-10","source":"Crossref","is-referenced-by-count":44,"title":["Targeting Adult Neurogenesis for Poststroke Therapy"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8090-7777","authenticated-orcid":true,"given":"Jianfei","family":"Lu","sequence":"first","affiliation":[{"name":"Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, 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