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To address this issue, C57BL\/6J mice were used to investigate the effects of 13 weeks of swim training on HFD-induced obesity and related insulin resistance and inflammation. Our results show that swim training can significantly prevent HFD-induced weight gain and increase resting energy expenditure without affecting food intake. The insulin sensitivity was enhanced in the HFD\u2009+\u2009swim group than in the HFD\u2009+\u2009sedentary group. Moreover, swim training considerably decreased serum LPS content and downregulates epididymis white adipose tissue (eWAT) expression of the inflammatory mediator<jats:italic>Tnf-\u03b1<\/jats:italic>,<jats:italic>Il-6<\/jats:italic>, and<jats:italic>Mcp-1<\/jats:italic>. 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