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The current study aimed to investigate the possible protective effects of green tea (<jats:italic>Camellia sinensis<\/jats:italic>) against perinatal nicotine\u2010induced behavioral alterations and oxidative stress in mice newborns. Pregnant mice received 50\u2009mg\/kg <jats:italic>C. sinensis<\/jats:italic> on gestational day 1 (PD1) to postnatal day 15 (D15) and were subcutaneously injected with 0.25\u2009mg\/kg nicotine from PD12 to D15. Nicotine\u2010exposed newborns showed significant delay in eye opening and hair appearance and declined body weight at birth and at D21. Nicotine induced neuromotor alterations in both male and female newborns evidenced by the suppressed righting, rotating, and cliff avoidance reflexes. Nicotine\u2010exposed newborns exhibited declined memory, learning, and equilibrium capabilities, as well as marked anxiety behavior. <jats:italic>C. sinensis<\/jats:italic> significantly improved the physical development, neuromotor maturation, and behavioral performance in nicotine\u2010exposed male and female newborns. In addition, <jats:italic>C. sinensis<\/jats:italic> prevented nicotine\u2010induced tissue injury and lipid peroxidation and enhanced antioxidant defenses in the cerebellum and medulla oblongata of male and female newborns. In conclusion, this study shows that <jats:italic>C. sinensis<\/jats:italic> confers protective effects against perinatal nicotine\u2010induced neurobehavioral alterations, tissue injury, and oxidative stress in mice newborns.<\/jats:p>","DOI":"10.1155\/2017\/5985219","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T21:00:52Z","timestamp":1494882052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Camellia sinensis<\/i> Prevents Perinatal Nicotine\u2010Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jamaan S.","family":"Ajarem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gadh","family":"Al-Basher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A.","family":"Allam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-6500","authenticated-orcid":false,"given":"Ayman M.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntw324"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200204000-00007"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.11.008"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200907-065DP"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-007-0251-y"},{"key":"e_1_2_7_6_2","first-page":"224","article-title":"High dose cotinine may induce neural tube defects in a chick embryo model","volume":"19","author":"Dalgic A.","year":"2009","journal-title":"Turkish Neurosurgery"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(96)80079-6"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20118"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.02.003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2009.10.008"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2003.06.001"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2012.09.003"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-011-0766-0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.01.020"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(93)90006-A"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.06.009"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.130"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0020724"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9521"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e31802d89eb"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2084"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2009.02.002"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.048"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.21092"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/15376520500194783"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2017.109.121"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.10.010"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(03)00009-3"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300544"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.7727\/wimj.2013.089"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2012.680205"},{"key":"e_1_2_7_32_2","first-page":"1215","article-title":"The effect of green tea extract on reproductive improvement in estradiol valerate-induced polycystic ovarian syndrome in rat","volume":"14","author":"Ghafurniyan H.","year":"2015","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/170981"},{"key":"e_1_2_7_34_2","first-page":"51","article-title":"Teratopharmacological and behavioral effects of coffee in mice","volume":"22","author":"Ajarem J. 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