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The purpose of this study is to determine the function of miR-373-3p in the progression of TSCC. Our results brought to light that miR-373-3p is markedly upregulated in clinical TSCC tissues compared with paired adjacent normal tissues and has significant correlation with a more aggressive TSCC phenotype in patients. Gain-of-function and loss-of-function studies revealed that ectopic miR-373-3p overexpression promoted the metastasis of TSCC cells. Notably, Wnt\/<jats:italic>\u03b2<\/jats:italic>-catenin signaling was hyperactivated in TSCC cells overexpressing miR-373-3p, and this pathway was responsible for the epithelial-mesenchymal transition (EMT) induced by miR-373-3p. Furthermore, miR-373-3p directly targeted and suppressed Dickkopf-1 (DKK1), a negative regulator of the Wnt\/<jats:italic>\u03b2<\/jats:italic>-catenin signaling cascade. These results demonstrate that, by directly targeting DKK1, miR-373-3p constitutively activated Wnt\/<jats:italic>\u03b2<\/jats:italic>-catenin signaling, thus promoting the EMT-induced metastasis of TSCC. Taken together, our findings reveal a new regulatory mechanism for miR-373-3p and suggest that miR-373-3p might be a potential target in TSCC therapy.<\/jats:p>","DOI":"10.1155\/2017\/6010926","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T16:06:25Z","timestamp":1488211585000},"page":"1-9","source":"Crossref","is-referenced-by-count":50,"title":["miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"bold-italic\">\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>-Catenin Pathway in Tongue Squamous Cell Carcinoma"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1128-2555","authenticated-orcid":true,"given":"Junquan","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, 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