{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:09:36Z","timestamp":1790125776387,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":109,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects of Traditional Chinese Medicine","award":["201307010"],"award-info":[{"award-number":["201307010"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. The aim of this study was to investigate the efficacy of herbal formula QiangGuYin (QGY) in postmenopausal women. <jats:italic>Materials and Methods<\/jats:italic>. A total of 240 participants from six clinical centers were randomly to receive alendronate 70\u2009mg\/week, QGY granules 20\u2009g\/day, and placebo. Primary end points were BMD changes over 6 and 12 months; secondary end points were bone turnover markers changes at 3, 6, 9, and 12 months. Safety was monitored by clinical adverse events reported during the follow\u2010up. <jats:italic>Results<\/jats:italic>. Of 240 women recruited, 218 completed the study. Significant BMD increases from baseline were observed over 6 and 12 months at each observed part both in QGY and alendronate compared with placebo (<jats:italic>p<\/jats:italic> &lt; 0.01). Alendronate\u2010treated subjects had significant decreases in <jats:italic>\u03b2<\/jats:italic>\u2010CTX compared to QGY\u2010treated subjects at each time point assessed (<jats:italic>p<\/jats:italic> &lt; 0.01). Reduction in t\u2010P1NP was only observed in the QGY group at 3 and 6 months (\u221223.81% and \u22123.07%, resp.). No significant difference was observed in the overall incidence of clinical adverse events among the alendronate group and the QGY group (5.0% versus 7.5%, <jats:italic>p<\/jats:italic> = 0.513). <jats:italic>Conclusion<\/jats:italic>. 1\u2010Year treatment with QGY demonstrated a safe statistical increase in BMD and new balance may be rebuilt after 9 months. This trail is registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/hvshowproject.aspx?id=6743\">ChiCTR-POC-16008026<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2017\/6062707","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T21:00:26Z","timestamp":1492722026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Traditional Chinese Medicine Product, QiangGuYin, on Bone Mineral Density and Bone Turnover in Chinese Postmenopausal Osteoporosis"],"prefix":"10.1155","volume":"2017","author":[{"given":"Zhen-Yu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Gen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Cheng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-1737","authenticated-orcid":false,"given":"Xiao-Lin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(10)70004-X"},{"key":"e_1_2_8_2_2","first-page":"2178","article-title":"A review on antiosteoporotic drugs","volume":"11","author":"Hu C.","year":"2008","journal-title":"Chinese Journal of Gerontology"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C246"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1430-3"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1513724"},{"key":"e_1_2_8_6_2","article-title":"Chinese herbal medicines for treating osteoporosis","volume":"3","author":"Liu Y.","year":"2014","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/752837"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1577-2"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1204061"},{"key":"e_1_2_8_10_2","article-title":"Identification of a beta-isomerized aspartyl residue within the C-terminal telopeptide alpha 1 chain of type I collagen. Possible relation to aging of bone","volume":"11","author":"Fledelius C.","year":"1996","journal-title":"Journal of Bone and Mineral Research"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(96)00165-2"},{"key":"e_1_2_8_12_2","volume-title":"General Guidelines for R&D of Traditional Chinese Medicine and Its Preclinical Evaluation and Clinical Trails in Prevention and Treatment of Osteoporosis and Fragility Fractures","author":"Chinese Osteoporosis Foundation","year":"2006"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01654"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.12.2163"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.4.613"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2015.05.011"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.01.024"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.02.019"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.08.002"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.04.092"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.04.031"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114459"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/6062707.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/6062707.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/6062707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:50:32Z","timestamp":1722909032000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/6062707"}},"subtitle":[],"editor":[{"given":"Farzad","family":"Deyhim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/6062707"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6062707","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2016-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6062707"}}