{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:29:52Z","timestamp":1765546192203,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T00:00:00Z","timestamp":1484438400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pharmaceutics"],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:p>The research was aimed at evaluating the antiglycation, antioxidant, and hepatoprotective properties of methanolic extract of<jats:italic> Anethum graveolens<\/jats:italic> (dill). The antioxidant properties, photochemical characteristics, and antiglycation effects of dill extract were measured. Carbon tetrachloride-induced hepatotoxic rats were used to show the hepatoprotective activity of dill leaves. Different concentration of dill extract (0.032, 0.065, 0.125, 0.25, 0.5, and 1\u2009mg\/mL) showed potential antioxidant ability. The extract of dill leaves significantly reduced AGEs formation and also fructosamine and protein carbonyl levels in rats\u2019 liver. Thiol groups\u2019 oxidation, amyloid cross-<jats:italic>\u03b2<\/jats:italic>, and protein fragmentation (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.00<\/mml:mn><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:math>) significantly reduced in treated rats. Liver damage markers significantly reduced in dill-treated animals (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>). Dill with potential antioxidant, antiglycation, and hepatoprotective effects can be suggested for treatment of diabetes complications.<\/jats:p>","DOI":"10.1155\/2017\/6081374","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T21:03:26Z","timestamp":1484514206000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Methanolic Extract of Dill Leaves Inhibits AGEs Formation and Shows Potential Hepatoprotective Effects in CCl<sub>4<\/sub> Induced Liver Toxicity in Rat"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3405-562X","authenticated-orcid":true,"given":"Ebrahim Abbasi","family":"Oshaghi","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraj","family":"Khodadadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mozafar","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidar","family":"Tavilani","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-5812","authenticated-orcid":true,"given":"Mohammad 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