{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:47:24Z","timestamp":1790912844839,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603287"],"award-info":[{"award-number":["81603287"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Gentiana macrophylla Radix, commonly known as Qin\u2010Jiao (QJ), was recorded alone to treat jaundice in Compendium of Materia Medica and has been frequently prescribed for treatment of liver disease in China. However, the underlying mechanism remains unknown. In the present work, QJ of 1,2\u2009g\/kg or silybin of 40\u2009mg\/kg (positive control) was orally given to rats for 7 days to verify the protective effect on acute liver damage induced by tetrachloride (CCl<jats:sub>4<\/jats:sub>). Together with serum biochemistry and histopathological examination, <jats:sup>1<\/jats:sup>H\u2010NMR based metabolomics work was carried out to investigate the efficacy. It turned out that QJ of 2\u2009g\/kg exerted comparable protective effect with positive control and partially recovered disturbed metabolism by CCl<jats:sub>4<\/jats:sub>. Multivariate analysis was conducted and metabolites altered significantly among groups were assigned and discussed, including betaine, glucose, lactate, creatine, and LDL\/VLDL. Metabolic regulations involved in QJ or silybin treatment were as follows: tricarboxylic acid (TCA) cycle, synthesis of LDL\/VLDL, and gluconeogenesis were enhanced, while betaine metabolism, glycolysis, creatine metabolism, synthesis of ketone bodies, amino acids metabolism, and <jats:italic>\u03b2<\/jats:italic>\u2010oxidation of fatty acids were suppressed. For the first time hepatoprotective effect of QJ on acute liver damage was revealed by <jats:sup>1<\/jats:sup>H\u2010NMR based metabolomics, prompting understanding of the underlying mechanism.<\/jats:p>","DOI":"10.1155\/2017\/6091589","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T23:31:44Z","timestamp":1509579104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<sup>1<\/sup>H\u2010NMR Based Serum Metabolomics Study to Investigate Hepatoprotective Effect of Qin\u2010Jiao on Carbon Tetrachloride\u2010Induced Acute Hepatotoxicity in Rats"],"prefix":"10.1155","volume":"2017","author":[{"given":"Zeyun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingpan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-6362","authenticated-orcid":false,"given":"Xin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3980-8563","authenticated-orcid":false,"given":"Xiaojian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2095-4964(14)60039-x"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep185"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.06.025"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127440"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8546-3-10"},{"key":"e_1_2_7_6_2","first-page":"341","article-title":"Anti-inflammatory and analgestic activity of G. macrophylla Pall flower and G. straminea maxim flower","volume":"27","author":"Zhang X. J. N.","year":"2012","journal-title":"Northwest Pharmaceutical Journal"},{"key":"e_1_2_7_7_2","article-title":"Screening of active part of  Gentiana macrophylla Pall. in the liver protection","volume":"29","author":"Zhang X. M. K.","year":"2014","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2874"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2015.04.004"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1624"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.10.014"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.anchem.1.031207.113026"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-006-0687-8"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.877490"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.10.019"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1260"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120950"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90625-U"},{"key":"e_1_2_7_19_2","first-page":"47","article-title":"Studies on liver-protection and promoting bile secretion of gentiopicroside","volume":"33","author":"Zhanwen C. C. L.","year":"2004","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.160469"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.138859"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-153718"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00332.2009"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.44.249"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037883"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4mb00072b"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301982200"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m508575200"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(62)90312-8"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.10.015"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4ra14660c"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.02.014"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066786"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059617"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.17.4.19565"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx049869b"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.6.2068S"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-010-0244-5"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1520-7560(199911\/12)15:6<412::aid-dmrr72>3.0.co;2-8"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00144-8"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03720.x"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/6091589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/6091589.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/6091589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:49:11Z","timestamp":1722908951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/6091589"}},"subtitle":[],"editor":[{"given":"Yohandra R.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/6091589"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6091589","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6091589"}}