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We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against<jats:italic> Neisseria meningitidis<\/jats:italic> in these cases of functional complement deficiency.<\/jats:p>","DOI":"10.1155\/2017\/6093695","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T17:03:15Z","timestamp":1500570195000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Fulminant Meningococcemia: It Is All in the Complement"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-9731","authenticated-orcid":true,"given":"Kellie L.","family":"Hawkins","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"},{"name":"Denver Health and Hospital Authority, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Denver Health and Hospital Authority, Denver, CO, USA"},{"name":"Division of Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-3521","authenticated-orcid":true,"given":"Sonia","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Denver Health and Hospital Authority, Denver, CO, USA"},{"name":"Division of Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Rowan","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"},{"name":"Denver Health and Hospital Authority, Denver, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90250-T"},{"issue":"1","key":"2","first-page":"911","volume":"5","year":"2009","journal-title":"Therapeutics and Clinical Risk Management"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061648"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6619a6"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1929-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-094136"},{"issue":"rr-2","key":"8","first-page":"1","volume":"62","year":"2013","journal-title":"MMWR Recomm Rep"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6527a3"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3503"},{"key":"12","year":"2012","journal-title":"Enferm Infec Microbol Clin"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12032"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-2924-y"}],"container-title":["Case Reports in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2017\/6093695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2017\/6093695.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criid\/2017\/6093695.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T17:03:15Z","timestamp":1500570195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/criid\/2017\/6093695\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":12,"alternative-id":["6093695","6093695"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6093695","relation":{},"ISSN":["2090-6625","2090-6633"],"issn-type":[{"value":"2090-6625","type":"print"},{"value":"2090-6633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}