{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:35:08Z","timestamp":1792128908311,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["CDS-APQ-00270-13"],"award-info":[{"award-number":["CDS-APQ-00270-13"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CDS-APQ-00270-13"],"award-info":[{"award-number":["CDS-APQ-00270-13"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CDS-APQ-00270-13"],"award-info":[{"award-number":["CDS-APQ-00270-13"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    A phytochemical study of\n                    <jats:italic>Fridericia formosa<\/jats:italic>\n                    (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI &gt; 38.2). For VACV-WR and HSV-1, EC50 values &gt; 200\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (\n                    <jats:bold>1<\/jats:bold>\n                    ), 2\u2032-\n                    <jats:italic>O-trans<\/jats:italic>\n                    -caffeoylmangiferin (\n                    <jats:bold>2<\/jats:bold>\n                    ), 2\u2032-\n                    <jats:italic>O-trans<\/jats:italic>\n                    -coumaroylmangiferin (\n                    <jats:bold>3<\/jats:bold>\n                    ), 2\u2032-\n                    <jats:italic>O<\/jats:italic>\n                    -trans-cinnamoylmangiferin (\n                    <jats:bold>5<\/jats:bold>\n                    ), and the flavonoid chrysin (\n                    <jats:bold>4<\/jats:bold>\n                    ). The most active compound was 2\u2032-\n                    <jats:italic>O-trans<\/jats:italic>\n                    -coumaroylmangiferin (\n                    <jats:bold>3<\/jats:bold>\n                    ) with SI &gt; 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs.\n                  <\/jats:p>","DOI":"10.1155\/2017\/6106959","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T17:00:35Z","timestamp":1496077235000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["Antiviral Activity of\n                    <i>Fridericia formosa<\/i>\n                    (Bureau) L. G. Lohmann (Bignoniaceae) Extracts and Constituents"],"prefix":"10.1155","volume":"2017","author":[{"given":"Geraldo C\u00e9lio","family":"Brand\u00e3o","sequence":"first","affiliation":[{"name":"Departamento de Farm\u00e1cia, Escola de Farm\u00e1cia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, 35.400-000 Ouro Preto, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna G.","family":"Kroon","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia, ICB, Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 D.","family":"Souza Filho","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, ICEX, Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-8909","authenticated-orcid":true,"given":"Ala\u00edde Braga","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos, Faculdade de Farm\u00e1cia, Universidade Federal de Minas Gerais, Av. Ant\u00f4nio Carlos 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18089919"},{"key":"2","year":"2016"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2010.06.019"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3201\/eid1504.081428"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3201\/eid1704.101581"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1086\/595856"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2010.02924.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2010005000035"},{"issue":"4","key":"10","first-page":"223","volume":"3","year":"2011","journal-title":"Journal of Chemical and Pharmaceutical Research"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2011.03146.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.5935\/1808-9569.20130007"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960884"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1987.190"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761999000400019"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600570631"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-005-0068-0"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)89890-8"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(96)00154-9"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1021\/np030100t"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1021\/np800406q"},{"key":"22","volume":"28","year":"1989"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/BF02978215"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422003000500003"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9673(02)01954-4"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.048"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.225"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1089\/109662003772519967"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.65325"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.836182"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16054264"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1328399"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1021\/np500124e"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200713165"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2008.00047.x"}],"container-title":["Journal of Tropical Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtm\/2017\/6106959.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtm\/2017\/6106959.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtm\/2017\/6106959.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T17:00:39Z","timestamp":1496077239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jtm\/2017\/6106959\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":34,"alternative-id":["6106959","6106959"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6106959","relation":{},"ISSN":["1687-9686","1687-9694"],"issn-type":[{"value":"1687-9686","type":"print"},{"value":"1687-9694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}