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The CPS of <jats:italic>M. ovipneumoniae<\/jats:italic> was first isolated and purified. Results showed that CPS had a cytotoxic effect by disrupting the integrity of mitochondrial membrane, accompanied with an increase of reactive oxygen species and decrease of mitochondrial membrane potential (\u0394\u03a8<jats:italic>m<\/jats:italic>). Of importance, the CPS exhibited an ability to induce caspase\u2010dependent cell apoptosis via both intrinsic and extrinsic apoptotic pathways. Mechanistically, the CPS induced extrinsic cell apoptosis by upregulating FAS\/FASL signaling proteins and cleaved\u2010caspase\u20108 and promoted a ROS\u2010dependent intrinsic cell apoptosis by activating a JNK and p38 signaling but not ERK1\/2 signaling of mitogen\u2010activated protein kinases (MAPK) pathways. These findings provide the first evidence that CPS of <jats:italic>M. ovipneumoniae<\/jats:italic> induces a caspase\u2010dependent apoptosis via both intrinsic and extrinsic apoptotic pathways in sheep bronchial epithelial cells, which may be mainly attributed by a ROS\u2010dependent JNK and p38 MAPK signaling pathways.<\/jats:p>","DOI":"10.1155\/2017\/6175841","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T21:01:18Z","timestamp":1488920478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Capsular Polysaccharide of <i>Mycoplasma ovipneumoniae<\/i> Induces Sheep Airway Epithelial Cell Apoptosis <i>via<\/i> ROS\u2010Dependent JNK\/P38 MAPK 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