{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:23:50Z","timestamp":1781619830340,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"Objective<\/jats:italic>. The aim of this meta-analysis is to evaluate the effects of dexmedetomidine on intraocular pressure (IOP) in patients with general anesthesia administered via intubation.Methods<\/jats:italic>. We searched randomized controlled trials (RCT) on the effects of intravenous injection of dexmedetomidine on IOP in patients with general anesthesia administered via intubation.Results<\/jats:italic>. The meta-analysis study showed that (1) a statistically significant difference [WMD = \u22123.40\u2009mmHg, 95% CI (\u22124.76, \u22122.04),P<\/mml:mi><<\/mml:mo>0.00001<\/mml:mn><\/mml:math>] was found between IOP of the two groups. (2) The IOP of the dexmedetomidine group that was administrated succinylcholine was lower than that of placebo group which was administrated succinylcholine [WMD = \u22124.13\u2009mmHg, 95% CI (\u22126.01, \u22122.25),P<\/mml:mi><<\/mml:mo>0.0001<\/mml:mn><\/mml:math>]. (3) Compared with the IOP of patients in the placebo group, patients with intubation in the dexmedetomidine group maintained a lower IOP [WMD = \u22123.10\u2009mmHg, 95% CI (\u22125.12, \u22121.07),P<\/mml:mi>=<\/mml:mo>0.003<\/mml:mn><\/mml:math>]. However, for incidences of bradycardia, the use of dexmedetomidine was higher than that of the placebo [RR = 0.23, 95% CI (0.07, 0.76),P<\/mml:mi>=<\/mml:mo>0.02<\/mml:mn><\/mml:math>].Conclusion<\/jats:italic>. This meta-analysis showed that, in many cases, dexmedetomidine can lower the IOP of patients with general anesthesia administered by intubation.<\/jats:p>","DOI":"10.1155\/2017\/6186832","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T07:33:49Z","timestamp":1486020829000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["The Effects of Intravenous Dexmedetomidine Injections on IOP in General Anesthesia Intubation: A Meta-Analysis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-791X","authenticated-orcid":true,"given":"Chengmao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China"},{"name":"Zhaoqing Medical College, Zhaoqing 526000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhaoqing Medical College, Zhaoqing 526000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-3772","authenticated-orcid":true,"given":"Lin","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/aco.0b013e328305e3ef"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0026-895X(25)08833-9","volume":"42","year":"1992","journal-title":"Molecular Pharmacology"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1354-1"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem040"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1089\/end.2014.0381"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen020"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/68.6.570"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.90611"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.152878"},{"key":"11","first-page":"19","volume":"29","year":"2013","journal-title":"Journal of Clinical Anesthesiology"},{"issue":"11","key":"10","first-page":"1272","volume":"19","year":"2014","journal-title":"The Chinese Journal of Clinical Pharmacology"},{"issue":"6","key":"12","first-page":"2019","volume":"33","year":"1992","journal-title":"Investigative Ophthalmology & Visual Science"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/6186832.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/6186832.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/6186832.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T23:01:40Z","timestamp":1749942100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/6186832\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":12,"alternative-id":["6186832","6186832"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6186832","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}