{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:28:09Z","timestamp":1759541289940,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Municipal Science & Technology Commission","award":["Z151100003815015","2011DFA31860","81473526"],"award-info":[{"award-number":["Z151100003815015","2011DFA31860","81473526"]}]},{"name":"Project of International Collaboration in Science and Technology Grant","award":["Z151100003815015","2011DFA31860","81473526"],"award-info":[{"award-number":["Z151100003815015","2011DFA31860","81473526"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Z151100003815015","2011DFA31860","81473526"],"award-info":[{"award-number":["Z151100003815015","2011DFA31860","81473526"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The aim of this study was to investigate the relationship between the combined effect of<jats:italic> MTHFR<\/jats:italic> C677T (rs1801133) and<jats:italic> EPHX2 <\/jats:italic>G860A (rs751141) polymorphism and ischemic stroke in Chinese T2DM patients. This case-control study included a total of 626 Chinese T2DM patients (236 T2DM patients with ischemic stroke and 390 T2DM patients without ischemic stroke). The rs1801133 and rs751141 were genotyped using real-time polymerase chain reaction. Statistical analysis was performed with SPSS 17.0. Results showed that the combined effect of<jats:italic> MTHFR<\/jats:italic> TT and<jats:italic> EPHX2<\/jats:italic> GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group (combined effect of<jats:italic> MTHFR<\/jats:italic> CC and<jats:italic> EPHX2<\/jats:italic> GA + AA genotypes; OR = 3.46 and OR = 3.42, resp.; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">001<\/mml:mn><\/mml:math> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">002<\/mml:mn><\/mml:math>, resp.). The A allele showed marked association with a lower risk of ischemic stroke in patients with the lowest Hcy levels under additive, recessive, and dominant genetic models (OR = 0.45, OR = 0.11, and OR = 0.44, resp.; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">002<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">035<\/mml:mn><\/mml:math>, and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">008<\/mml:mn><\/mml:math>, resp.), which was not observed in medium or high Hcy level groups. In conclusion, the T allele of rs1801133 and the G allele of rs751141 may be risk factors of ischemic stroke in the Chinese T2DM population.<\/jats:p>","DOI":"10.1155\/2017\/6216205","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T17:01:47Z","timestamp":1490029307000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Synergistic Effect of the<i> MTHFR<\/i> C677T and<i> EPHX2<\/i> G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients"],"prefix":"10.1155","volume":"2017","author":[{"given":"Liang","family":"Ma","sequence":"first","affiliation":[{"name":"Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China"},{"name":"Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-0283","authenticated-orcid":true,"given":"Yongwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Yan","sequence":"additional","affiliation":[{"name":"Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-5260","authenticated-orcid":true,"given":"Haojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8904-3060","authenticated-orcid":true,"given":"Yongtong","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-2276","authenticated-orcid":true,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"},{"name":"Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, 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