{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:30:09Z","timestamp":1761744609033,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Genetics"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Cardiotoxicity has been extensively reported in venlafaxine (VEN) overdoses. Asthenia is also among the common side effects described for this antidepressant. VEN is metabolized mainly by CYP2D6 and to a minor extent by CYP2C19 to the major active metabolite O-desmethylvenlafaxine (ODV). Altered pharmacokinetic parameters in patients with polymorphisms in the<jats:italic> CYP2D6<\/jats:italic> and<jats:italic> CYP2C19<\/jats:italic> genes that result in decreased enzymatic activity have been documented. Here we describe a patient case of VEN associated palpitations and asthenia. The patient takes VEN extended release 150\u2009mg twice daily. Genotyping confirmed the patient is a poor metabolizer for CYP2D6 and an intermediate metabolizer for CYP2C19. We propose that the palpitations and asthenia are related to sustained VEN exposure due to reduced metabolism.<\/jats:p>","DOI":"10.1155\/2017\/6236714","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T19:31:21Z","timestamp":1508182281000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Palpitations and Asthenia Associated with Venlafaxine in a CYP2D6 Poor Metabolizer and CYP2C19 Intermediate Metabolizer"],"prefix":"10.1155","volume":"2017","author":[{"given":"Sofia","family":"Garcia","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schuh","sequence":"additional","affiliation":[{"name":"School of Health Sciences, College of Medicine, Mayo Clinic, Jacksonville, FL, 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