{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:37Z","timestamp":1790232577579,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008816","name":"University of Sri Jayewardenepura","doi-asserted-by":"publisher","award":["ASP\/01\/RE\/MED\/2017\/28"],"award-info":[{"award-number":["ASP\/01\/RE\/MED\/2017\/28"]}],"id":[{"id":"10.13039\/501100008816","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008816","name":"University of Sri Jayewardenepura","doi-asserted-by":"publisher","award":["NSF\/SCH\/2015\/04"],"award-info":[{"award-number":["NSF\/SCH\/2015\/04"]}],"id":[{"id":"10.13039\/501100008816","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation Research Scholarship","award":["ASP\/01\/RE\/MED\/2017\/28"],"award-info":[{"award-number":["ASP\/01\/RE\/MED\/2017\/28"]}]},{"name":"National Science Foundation Research Scholarship","award":["NSF\/SCH\/2015\/04"],"award-info":[{"award-number":["NSF\/SCH\/2015\/04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The pro- and anti-inflammatory cytokines play an important role in the immune response against<jats:italic>H. pylori<\/jats:italic>infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in<jats:italic>H. pylori<\/jats:italic>infection and resulting gastric inflammation.<jats:italic>Objective<\/jats:italic>. The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-<jats:italic>\u03b1<\/jats:italic>) in<jats:italic>H. pylori<\/jats:italic>-infected patients and healthy controls and to understand their association with<jats:italic>H. pylori<\/jats:italic>infection and disease severity.<jats:italic>Results<\/jats:italic>. The expression levels of IL-17 and IL-23 were significantly higher in<jats:italic>H. pylori-<\/jats:italic>infected patients. The expression of IL-21 was also higher in<jats:italic>H. pylori-<\/jats:italic>positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis.<jats:italic>Conclusion<\/jats:italic>. The proinflammatory cytokine, IL-17, shows a significant association with<jats:italic>H. pylori<\/jats:italic>infection and disease severity in a Sri Lankan dyspeptic patient population.<\/jats:p>","DOI":"10.1155\/2017\/6265150","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T23:32:10Z","timestamp":1513553530000},"page":"1-7","source":"Crossref","is-referenced-by-count":28,"title":["Proinflammatory Cytokine IL-17 Shows a Significant Association with<i>Helicobacter pylori<\/i>Infection and Disease Severity"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-3117","authenticated-orcid":true,"given":"Piyumali Sandareka","family":"Arachchi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri 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