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Chinese medicine syndrome diagnosis is the key requisite in the treatment of male infertility with traditional Chinese medicine (TCM). Kidney\u2010Yang deficiency syndrome (KYDS) is the critical Chinese medicine syndrome of male infertility. To explore the modernized mechanisms of KYDS in male infertility, this study aims to investigate the metabolomics of males with KYDS. <jats:italic>Methods.<\/jats:italic> The gas chromatography\u2010mass spectrometry method was applied to analyze the plasma samples of 67 infertile males with KYDS compared with 55 age\u2010matched healthy controls. The chemometric methods including principal component and partial least squares\u2010discriminate analyses were employed to identify the potential biochemical patterns. With the help of the variable importance for the projection and receiver operating characteristic curve analyses, the potential biomarkers were extracted to define the clinical utility. Simultaneously the high\u2010quality KEGG metabolic pathways database was used to identify the related metabolic pathways. <jats:italic>Results<\/jats:italic>. The metabolomics profiles of infertile males with KYDS including 10 potential biomarkers and six metabolic pathways were identified. They precisely distinguished infertile males with KYDS from healthy controls. <jats:italic>Conclusions.<\/jats:italic> These potential biomarkers and pathways suggest the substantial basis of infertile males with KYDS. The metabolomics profiles highlight the modernized mechanisms of infertile males with KYDS.<\/jats:p>","DOI":"10.1155\/2017\/6270195","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T21:00:55Z","timestamp":1506373255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Plasma Metabolomics Analysis Based on GC\u2010MS in Infertile Males with Kidney\u2010Yang Deficiency Syndrome"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3649-8181","authenticated-orcid":false,"given":"Piao","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8829-3319","authenticated-orcid":false,"given":"Chunhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanjin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-6017","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-533X","authenticated-orcid":false,"given":"Jiekun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.111"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.08.006"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137433"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3282f88e22"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1345589"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(15)30072-8"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.127"},{"key":"e_1_2_10_8_2","first-page":"38","article-title":"The effects and prospects of the integration of traditional Chinese medicine and Western medicine on andrology in China","volume":"27","author":"Li H. 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