{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:46:58Z","timestamp":1787510818105,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Previous studies assessing various cytokines in the critically ill\/injured have been uninformative in terms of translating to clinical care management. Animal abdominal sepsis work suggests that enhanced intraperitoneal (IP) clearance of Damage-Associated Molecular Patterns (DAMPs) improves outcome. Thus measuring the responses of DAMPs offers alternate potential insights and a representative DAMP, High Mobility Group Box-1 protein (HMGB-1), was considered. While IP biomediators are being recognized in critical illness\/trauma, HMGB-1 behaviour has not been examined in open abdomen (OA) management.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A modified protocol for HMGB-1 detection was used to examine plasma\/IP fluid samples from 44 critically ill\/injured OA patients enrolled in a randomized controlled trial comparing two negative pressure peritoneal therapies (NPPT): Active NPPT (ANPPT) and Barker\u2019s Vacuum Pack NPPT (BVP). Samples were collected and analyzed at the time of laparotomy and at 24 and 48 hours after.\n                    <jats:italic>Results<\/jats:italic>\n                    . There were no statistically significant differences in survivor versus nonsurvivor HMGB-1 plasma or IP concentrations at baseline, 24 hours, or 48 hours. However, plasma HMGB-1 levels tended to increase continuously in the BVP cohort.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . HMGB-1 appeared to behave differently between NPPT cohorts. Further studies are needed to elucidate the relationship of HMGB-1 and outcomes in septic\/injured patients.\n                  <\/jats:p>","DOI":"10.1155\/2017\/6305387","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T16:01:19Z","timestamp":1487088079000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["High Mobility Group Box-1 Protein and Outcomes in Critically Ill Surgical Patients Requiring Open Abdominal Management"],"prefix":"10.1155","volume":"2017","author":[{"given":"Michelle S.","family":"Malig","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig N.","family":"Jenne","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada"},{"name":"Critical Care Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad G.","family":"Ball","sequence":"additional","affiliation":[{"name":"Critical Care Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of General Surgery, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwen","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Regional Trauma Program, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-5919","authenticated-orcid":true,"given":"Andrew 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