{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T23:50:22Z","timestamp":1762473022504,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":325,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Sunitinib, a multitargeted tyrosine kinase inhibitor (TKI), is currently the standard of care for patients with metastatic renal cell carcinoma. Renal adverse events associated with sunitinib include proteinuria, renal insufficiency secondary to focal segmental glomerulosclerosis (FSGS), and thrombotic microangiopathy. We describe the second reported instance of biopsy\u2010proven sunitinib\u2010induced acute interstitial nephritis (AIN), in a challenging case complicated by thrombocytopenia. The case illustrates the importance of early diagnosis and intervention in ensuring long\u2010term recovery from renal complications. Four other cases of AIN reported along with inhibition of the vascular endothelial growth factor (VEGF) by either TKI (sunitinib and sorafenib) or antibodies (bevacizumab) suggest a possible class effect. Given our experience, we recommend monitoring renal function with VEGF inhibition, and in the case of renal failure in the setting of an unclear diagnosis, we recommend prompt biopsy.<\/jats:p>","DOI":"10.1155\/2017\/6328204","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T18:31:28Z","timestamp":1511375488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sunitinib\u2010Induced Acute Interstitial Nephritis in a Thrombocytopenic Renal Cell Cancer Patient"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-1807","authenticated-orcid":false,"given":"Ibrahim","family":"Azar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saghi","family":"Esfandiarifard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Sinai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Wazir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llewellyn","family":"Foulke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Mehdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_5_1_2","unstructured":"National Comprehensive Cancer Network Kidney cancer (version 2) 2017 https:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/kidney.pdf."},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.01.005"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.71"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn657"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000360087"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2007.12.011"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn625"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.3602"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/11318860-000000000-00000"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm199"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H635"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155212466421"},{"key":"e_1_2_5_13_2","first-page":"1295","article-title":"Sunitinib induced immune thrombocytopenia","volume":"14","author":"Shekarriz R.","year":"2015","journal-title":"Iranian Journal of Pharmaceutical Research"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2017\/6328204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2017\/6328204.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/6328204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T23:48:54Z","timestamp":1762472934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/6328204"}},"subtitle":[],"editor":[{"given":"Peter F.","family":"Lenehan","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/6328204"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6328204","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"type":"print","value":"2090-6706"},{"type":"electronic","value":"2090-6714"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6328204"}}