{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:38:17Z","timestamp":1764873497584,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry for Health \u201cRicerca Corrente\u201d I.R.C.C.S. Policlinico San Donato","award":["9.14.2"],"award-info":[{"award-number":["9.14.2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>An imbalance between degradation and reconstruction of the aortic wall is one of the leading causes of acute aortic dissection (AAD). Vitamin D seems an intriguing molecule to explore in the field of AAD since it improves endothelial function and protects smooth muscle cells from inflammation-induced remodeling, calcification, and loss of function, all events which are strongly related to the aging process. We quantified 25-hydroxy vitamin D, calcium, parathormone, bone alkaline phosphatase, and osteocalcin levels in 24 elderly AAD patients to identify a potential pathological implication of these molecules in AAD. Median 25-hydroxy vitamin D (10.75\u2009ng\/mL, 25th\u201375th percentiles: 6.86\u201319.23\u2009ng\/mL) and calcium levels (8.70\u2009mg\/dL, 25th\u201375th percentiles: 7.30\u20138.80\u2009mg\/dL) suggested hypovitaminosis D and a moderate hypocalcemia. Thirty-eight percent of AAD patients had severe (&lt;10\u2009ng\/mL), 38% moderate (10\u201320\u2009ng\/mL), and 24% mild 25-hydroxy vitamin D deficiency (20\u201330\u2009ng\/mL). A significant inverse correlation was observed between 25OHD and osteocalcin levels. All the other molecules were unchanged. A condition of hypovitaminosis D associated to an increase in osteocalcin levels is present in AAD patients. The identification of these molecules as new factors involved in AAD may be helpful to identify individuals at high risk as well to study preventing strategies.<\/jats:p>","DOI":"10.1155\/2017\/6412531","type":"journal-article","created":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T17:03:27Z","timestamp":1499015007000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D Deficiency Is Associated with Increased Osteocalcin Levels in Acute Aortic Dissection: A Pilot Study on Elderly Patients"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-654X","authenticated-orcid":true,"given":"Elena","family":"Vianello","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-0780","authenticated-orcid":true,"given":"Elena","family":"Dozio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy"},{"name":"Laboratory of Molecular Pathology, I.R.C.C.S. Policlinico San Donato, Via R. Morandi 30, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-8357","authenticated-orcid":true,"given":"Alessandra","family":"Barassi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universit\u00e0 degli Studi di Milano, Via A. Di Rudin\u00ec 8, 20142 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4863-178X","authenticated-orcid":true,"given":"Lorenza","family":"Tacchini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lamont","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Universit\u00e0 degli Studi di Milano, Via A. Di Rudin\u00ec 8, 20142 Milan, Italy"},{"name":"Randox Laboratories Ltd., R&D, 55 Diamond Road, Crumlin, Antrim, Belfast BT29 4QY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santi","family":"Trimarchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy"},{"name":"Thoracic Aortic Research Center, I.R.C.C.S. Policlinico San Donato, Piazza E. Malan 1, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano M.","family":"Marrocco-Trischitta","sequence":"additional","affiliation":[{"name":"Thoracic Aortic Research Center, I.R.C.C.S. Policlinico San Donato, Piazza E. Malan 1, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-7697","authenticated-orcid":true,"given":"Massimiliano M.","family":"Corsi Romanelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milan, Italy"},{"name":"Laboratory Medicine Operative Unit-1, Clinical Pathology, I.R.C.C.S. Policlinico San Donato, Piazza E. Malan 1, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.06.067"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.165886"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0784"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.513655"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328312c33f"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2010.06.013"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.03.031"},{"issue":"7","key":"8","first-page":"1931","volume":"96","year":"2010","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000219"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.03.015"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.55"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.08.012"},{"issue":"3","key":"13","first-page":"563","volume":"29","year":"2015","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.07.031"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.10.096"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.05.911"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1744"},{"key":"18","first-page":"S97","volume":"13","year":"2016","journal-title":"Annals of the American Thoracic Society"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2011.11.010"},{"issue":"3","key":"20","first-page":"222","volume":"37","year":"2007","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0953"},{"issue":"7","key":"22","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","volume":"283","year":"2000","journal-title":"Journal of the American Medical Association"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1159"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0445"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0213"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.186"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9512-z"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv184"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv109"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.11.002"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307530"},{"issue":"4","key":"32","first-page":"279","volume":"44","year":"2016","journal-title":"T\u00fcrk Kardiyoloji Derne\u011fi Ar\u015fivi"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.07.019"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.329110"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-965"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu225"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102412"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331746"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2017\/6412531.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2017\/6412531.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2017\/6412531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T17:03:31Z","timestamp":1499015011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2017\/6412531\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":38,"alternative-id":["6412531","6412531"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6412531","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"type":"print","value":"0962-9351"},{"type":"electronic","value":"1466-1861"}],"subject":[],"published":{"date-parts":[[2017]]}}}