{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:23:33Z","timestamp":1780392213713,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non\u2010Hodgkin\u2019s lymphoma characterized by malignant B cells with reactive T lymphocytes. The pathophysiology is thought to involve cytokine\u2010mediated evasion of T cell immune response by malignant B cells. It usually presents at an advanced stage with extranodal involvement. An extremely unusual manifestation of the disease is hemophagocytic lymphohistiocytosis (HLH) which is a hyperinflammatory disorder. We present a case of a 43\u2010year\u2010old male who presented with recurrent fever and recent radiologic imaging showing splenomegaly and right inguinal lymphadenopathy. On presentation, he had a fever of 105\u00b0F. Laboratory work\u2010up was consistent with pancytopenia, elevated lactate dehydrogenase, elevated D\u2010dimer, and a ferritin of 24,247\u2009ng\/mL. The patient was started on steroid therapy. An excisional biopsy of the right inguinal lymph node was consistent with a diagnosis of THRLBCL and the patient subsequently received six cycles of chemotherapy with R\u2010CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) after which a PET\u2010CT scan showed no evidence of biologically active disease and ferritin was down to 822\u2009ng\/mL. We discuss the clinical manifestations and diagnostic and therapeutic considerations of this rare disease along with a review of reported cases in the literature.<\/jats:p>","DOI":"10.1155\/2017\/6428461","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T17:02:09Z","timestamp":1503334929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-5438","authenticated-orcid":false,"given":"Uroosa","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-5052","authenticated-orcid":false,"given":"Gwenalyn","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Saqib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafinaz","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701559124"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1165-z"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)61048-x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22416"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.123562"},{"key":"e_1_2_6_7_2","article-title":"T-cell\/histiocyte-rich large B-cell lymphoma masquerading as autoimmune hepatitis with clinical features of hemophagocytic lymphohistiocytosis","volume":"5","author":"Mehta M.","year":"2015","journal-title":"Journal of Gastrointestinal & Digestive System"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-016-0065-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lrr.2014.05.004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008212516595"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-397604"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12190"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.009647"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0855"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.178"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2017\/6428461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2017\/6428461.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/6428461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T23:48:59Z","timestamp":1762472939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/6428461"}},"subtitle":[],"editor":[{"given":"Jeanine M.","family":"Buchanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/6428461"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6428461","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6428461"}}