{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:28:23Z","timestamp":1791664103853,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Health System High-Level Technical Talents Training Fund","award":["2015-3-083"],"award-info":[{"award-number":["2015-3-083"]}]},{"name":"Beijing Health System High-Level Technical Talents Training Fund","award":["81473062"],"award-info":[{"award-number":["81473062"]}]},{"name":"Beijing Health System High-Level Technical Talents Training Fund","award":["2013CB530605"],"award-info":[{"award-number":["2013CB530605"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2015-3-083"],"award-info":[{"award-number":["2015-3-083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473062"],"award-info":[{"award-number":["81473062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2013CB530605"],"award-info":[{"award-number":["2013CB530605"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2015-3-083"],"award-info":[{"award-number":["2015-3-083"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["81473062"],"award-info":[{"award-number":["81473062"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2013CB530605"],"award-info":[{"award-number":["2013CB530605"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (<jats:italic>MC4R<\/jats:italic>) gene and rs6265 near the brain-derived neurotrophic factor (<jats:italic>BDNF<\/jats:italic>) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNPs and adiponectin that has a regulatory role in glucose and lipid metabolism. <jats:italic>Methods<\/jats:italic>. We examined the associations of the SNPs with adiponectin in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. A total of 3503 children participated in the study. <jats:italic>Results<\/jats:italic>. The SNP rs6265 was significantly associated with adiponectin under an additive model (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math> and 0.024, resp.) after adjustment for age, gender, and BMI or obesity statuses. The SNP rs17782313 was significantly associated with low adiponectin under a recessive model. No statistical significance was found between the two SNPs and low adiponectin after correction for multiple testing. <jats:italic>Conclusion<\/jats:italic>. We demonstrate for the first time that the SNP rs17782313 near <jats:italic>MC4R<\/jats:italic> and the SNP rs6265 near <jats:italic>BDNF<\/jats:italic> are associated with adiponectin in Chinese children. These novel findings provide important evidence that adiponectin possibly mediates MC4R and BDNF involved in obesity.<\/jats:p>","DOI":"10.1155\/2017\/6437542","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T21:07:38Z","timestamp":1489612058000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-8379","authenticated-orcid":true,"given":"Lijun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-8447","authenticated-orcid":true,"given":"Jie","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1080\/17477160600586747"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2011.00965.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3310\/hta19430"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.186"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.86"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.287"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.274"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/ng.301"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.159"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0273"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1465"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2007.04.007"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/658913"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.882321"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.77"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00301.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/nature21025"},{"issue":"6","key":"18","first-page":"469","volume":"27","year":"2006","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"6","key":"19","first-page":"390","volume":"18","year":"2005","journal-title":"Biomedical and Environmental Sciences"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1051"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2042"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2017\/6437542.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2017\/6437542.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2017\/6437542.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:05:47Z","timestamp":1589738747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ije\/2017\/6437542\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"alternative-id":["6437542","6437542"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6437542","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"value":"1687-8337","type":"print"},{"value":"1687-8345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}