{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:32:47Z","timestamp":1761823967883,"version":"3.37.3"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Research Funds for the National Key Research and Development Program of China","award":["2016YFD0500907","CAAS-ASTIP-2016-LVRI-06"],"award-info":[{"award-number":["2016YFD0500907","CAAS-ASTIP-2016-LVRI-06"]}]},{"DOI":"10.13039\/501100012421","name":"Agricultural Science and Technology Innovation Program","doi-asserted-by":"crossref","award":["2016YFD0500907","CAAS-ASTIP-2016-LVRI-06"],"award-info":[{"award-number":["2016YFD0500907","CAAS-ASTIP-2016-LVRI-06"]}],"id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Ectromelia virus (ECTV), the causative agent of mousepox, has emerged as a valuable model for investigating the host-<jats:italic>Orthopoxvirus<\/jats:italic>relationship as it relates to pathogenesis and the immune response. ECTV is a mouse-specific virus and causes high mortality in susceptible mice strains, including BALB\/c and C3H, whereas C57BL\/6 and 129 strains are resistant to the disease. To understand the host genetic factors in different mouse strains during the ECTV infection, we carried out a microarray analysis of spleen tissues derived from BALB\/c and C57BL\/6 mice, respectively, at 3 and 10 days after ECTV infection. Differential Expression of Genes (DEGs) analyses revealed distinct differences in the gene profiles of susceptible and resistant mice. The susceptible BALB\/c mice generated more DEGs than the resistant C57BL\/6 mice. Additionally, gene ontology and KEGG pathway analysis showed the DEGs of susceptible mice were involved in innate immunity, apoptosis, metabolism, and cancer-related pathways, while the DEGs of resistant mice were largely involved in MAPK signaling and leukocyte transendothelial migration. Furthermore, the BALB\/c mice showed a strong induction of interferon-induced genes, which, however, were weaker in the C57BL\/6 mice. Collectively, the differential transcriptome profiles of susceptible and resistant mouse strains with ECTV infection will be crucial for further uncovering the molecular mechanisms of the host-<jats:italic>Orthopoxvirus<\/jats:italic>interaction.<\/jats:p>","DOI":"10.1155\/2017\/6456180","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T23:54:26Z","timestamp":1513900466000},"page":"1-13","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection"],"prefix":"10.1155","volume":"2017","author":[{"given":"Wen-Yu","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai-Jie","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Bing","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Lanzhou University, Lanzhou 730000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1171-7931","authenticated-orcid":true,"given":"Zhi-Zhong","family":"Jing","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Agriculture Ministry, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1099"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100118"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004108"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.345.6200.1010-a"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/514544a"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810378649"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3201\/eid2304.161041"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/v8070203"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81090-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-876-4_11"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2015.10.001"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402949101"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12054"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2478\/pjvs-2013-0004"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1128\/JVI.55.3.890-891.1985","volume":"55","year":"1985","journal-title":"Journal of Virology"},{"key":"16","first-page":"129","volume":"281","year":"2007","journal-title":"Novartis Foundation Symposium"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005342"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.015"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.022500599"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040030"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100282"},{"issue":"10","key":"22","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.4049\/jimmunol.175.10.6829","volume":"175","year":"2005","journal-title":"Journal of Immunology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002475"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202143109"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01150-14"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118685"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.04.015"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.015"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33940"},{"issue":"10","key":"30","volume":"9","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"31","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1128\/JVI.72.9.7703-7706.1998","volume":"72","year":"1998","journal-title":"Journal of Virology"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2010.04813.x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004941"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803985"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007512"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.12.008"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.11.012"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02176-14"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-723"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a118408"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-61"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-452"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.09.003"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003904"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.04.004"},{"issue":"17","key":"46","first-page":"30054","volume":"s1471-4906","year":"2017","journal-title":"Trends in Microbiology"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.05.009"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.004"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.4161\/rna.7.6.14249"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220456110"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00007"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202714"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02061-06"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904117"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004526"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13950"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01927-06"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00256-11"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/6456180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/6456180.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/6456180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T18:19:15Z","timestamp":1603563555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/6456180\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":58,"alternative-id":["6456180","6456180"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6456180","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2017]]}}}