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Extensive research has been conducted into the role played by oxidative stress and inflammation in the functional transformations associated with the progression of CVDs, while the research findings from these investigations have been both fruitful and informative. In view of the adverse secondary effects that result from the clinical administration of many synthetic medications, research which explored the treatment of severe and long\u2010lasting conditions, including CVDs, has primarily centered on the potential benefits displayed by natural agents, one of which is food protein\u2010based bioactive peptides. Most importantly, previous research has revealed the possible benefits associated with these products\u2019 anti\u2010inflammatory and antioxidant characteristics. In light of these considerations, this paper aims to review the degree to which ovotransferrin (otrf, also referred to as conalbumin) and otrf\u2010derived peptides, including IRW, IQW, and KVREGT, are, by virtue of their anti\u2010inflammatory and antioxidant characteristics, viable treatment agents for endothelial dysfunction and the prevention of CVD.<\/jats:p>","DOI":"10.1155\/2017\/6504518","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T17:31:51Z","timestamp":1489426311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Utility of Ovotransferrin and Ovotransferrin\u2010Derived Peptides as Possible Candidates in the Clinical Treatment of Cardiovascular Diseases"],"prefix":"10.1155","volume":"2017","author":[{"given":"Shuang","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanhui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4803-8289","authenticated-orcid":false,"given":"Xiaosong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-8444","authenticated-orcid":false,"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.001470"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161282109150103213605"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61682-2"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2013.10.016"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.077487"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666141013120459"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3519"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.5897\/ajpp12.684"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520120122"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.07.014"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.08.004"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.6.C1375"},{"key":"e_1_2_8_13_2","article-title":"Oxidative stress and endothelial dysfunction in hypertension and diabetes","volume":"40","author":"Huang Y.","year":"2013","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"e_1_2_8_14_2","first-page":"S220","article-title":"Insulin resistance and endothelial dysfunction in patients with hypertension and metabolic syndrome","volume":"27","author":"Albarran M. 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