{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:16:32Z","timestamp":1753881392690,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,3]],"date-time":"2017-12-03T00:00:00Z","timestamp":1512259200000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The Traditional Chinese Medicine (TCM) Qi\u2010supplementing therapy has been used widely for treating myasthenia gravis (MG) in China. The purpose of this meta\u2010analysis was to evaluate the efficacy and safety of Qi\u2010supplementing therapy as an adjunctive therapy in MG patients. <jats:italic>Methods<\/jats:italic>. Seven electronic databases were searched through June 2016. Randomized controlled trials (RCTs) evaluating the add\u2010on effect of Qi\u2010supplementing therapy in MG patients were included. The outcome measures were the total effective rate, relapse rate, and adverse events. <jats:italic>Results<\/jats:italic>. Twenty\u2010three RCTs involving 1,691 MG patients were included. The included studies were of low\u2010to\u2010moderate quality. Meta\u2010analysis showed that Qi\u2010supplementing therapy combined with Western medicine (WM) significantly improved the total response rate and reduced the relapse risk during 6\u201324 months of follow\u2010up. Subgroup analysis showed that Qi\u2010supplementing therapy only affected the total response rate within the first 6 months of treatment. Moreover, the rate of adverse events was lower with the addition of Qi\u2010supplementing therapy to WM than with WM only. <jats:italic>Conclusions<\/jats:italic>. Short\u2010term Qi\u2010supplementing therapy combined with WM appears to be superior to WM for improving the total response rate and reducing the relapse rate. However, more high\u2010quality RCTs are warranted owing to methodological flaws of previous trials.<\/jats:p>","DOI":"10.1155\/2017\/6512572","type":"journal-article","created":{"date-parts":[[2017,12,3]],"date-time":"2017-12-03T23:31:38Z","timestamp":1512343898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of the TCM Qi\u2010Supplementing Therapy in Patients with Myasthenia Gravis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-7796","authenticated-orcid":false,"given":"Xi-qian","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-9224","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-huan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-ran","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,3]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(09)70063-8"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318217e735"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12703"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24697"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12217"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12439"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-016-0756-3"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.033"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.019232"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12599"},{"key":"e_1_2_8_12_2","first-page":"33","article-title":"Treatment of 52 cases of myasthenia gravis by warming kidney, invigorating spleen, replenishing qi and activating blood method","volume":"31","author":"Wang S. H.","year":"1999","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"e_1_2_8_13_2","first-page":"23","volume-title":"Journal of Beijing University of Traditional Chinese Medicine","author":"Jiang J. D.","year":"2003"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-341-5"},{"key":"e_1_2_8_15_2","article-title":"Treatment of 87 cases of ocular myasthenia gravis in children with combination of TCM and Western Medicine","author":"Zhang Y. Y.","year":"2006","journal-title":"Shaanxi Journal of Traditional Chinese Medicine"},{"key":"e_1_2_8_16_2","first-page":"49","volume-title":"Journal of Sichuan Traditional Chinese Medicine","author":"Zhang W. Y.","year":"2006"},{"key":"e_1_2_8_17_2","first-page":"1649","article-title":"Clinical experience of treating myasthenia gravis 20 cases with integrated traditional Chinese and Western Medicine","volume":"16","author":"Lu A. Y.","year":"2007","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"volume-title":"Treatment of myasthenia gravis 30 cases by traditional Chinese Medicine combined Western medicine China Foreign Med Treat","year":"2007","author":"Ouyang Q.","key":"e_1_2_8_18_2"},{"key":"e_1_2_8_19_2","first-page":"173","article-title":"Treatment of 76 cases of ocular myasthenia gravis in children with integrated Traditional Chinese Medicine and Western medicine","volume":"17","author":"Zhang L.","year":"2007","journal-title":"Shenzhen Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"e_1_2_8_20_2","first-page":"1242","article-title":"Clinical observation on treatment of myasthenia gravis with invigorating spleen and replenishing qi","volume":"6","author":"Yang J. H.","year":"2008","journal-title":"Chin J Integr Med Cardio-\/Cerebrovascu Dis"},{"volume-title":"Clinical and experimental study on treatment of myasthenia gravis with Huangqi compound","year":"2009","author":"Niu G. H.","key":"e_1_2_8_21_2"},{"key":"e_1_2_8_22_2","first-page":"58","volume-title":"Jiangxi Journal of Traditional Chinese Medicine","author":"Lv G. X.","year":"2010"},{"key":"e_1_2_8_23_2","article-title":"Combining traditional Chinese and Western medicine in the treatment of drooping eyelids with myasthenia gravis","author":"Xu X. M.","year":"2011","journal-title":"China Medical Herald"},{"key":"e_1_2_8_24_2","first-page":"31","article-title":"Integrated traditional Chinese and Western medicine in the treatment of 30 cases of myasthenia gravis","author":"Wang Y. Q.","year":"2012","journal-title":"Shandong Journal Traditional Chinese Medicine"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(13)60146-6"},{"key":"e_1_2_8_26_2","first-page":"283","article-title":"Buzhong Yiqi Decoction combined with Western medicine in the treatment of 36 cases of children myasthenia gravis ptosis","volume":"34","author":"Ma T.","year":"2013","journal-title":"Shaanxi Journal Traditional Chinese Medicine"},{"key":"e_1_2_8_27_2","first-page":"236","volume-title":"Traditional Chinese Medicine","author":"Chen W.","year":"2013"},{"volume-title":"Clinical study of Yiqi Shengti Decoction on myasthenia gravis","year":"2013","author":"Xia L. X.","key":"e_1_2_8_28_2"},{"key":"e_1_2_8_29_2","first-page":"136","article-title":"Comparison of the clinical efficacy with Zhongjiling and glucocorticoid in the treatment of myasthenia gravis","volume":"12","author":"Shen Y.","year":"2014","journal-title":"Chin Foreign Med Res"},{"key":"e_1_2_8_30_2","first-page":"2432","article-title":"ntegrated traditional Chinese and Western medicine in the treatment of 18 cases of myasthenia gravis","volume":"34","author":"Huang Y. Y.","year":"2014","journal-title":"Henan Traditional Chinese Medicine"},{"volume-title":"Clinical Efficacy of Yiqi Chushi Recipe in Treating Myasthenia Gravis. Res Integr Traditl Chin West Med","year":"2014","author":"Shuang XP.","key":"e_1_2_8_31_2"},{"volume-title":"The eleventh Chinese Academy of Chinese and Western Integrative Neuroscience (C)","year":"2015","author":"Yuan Y.","key":"e_1_2_8_32_2"},{"key":"e_1_2_8_33_2","first-page":"28","article-title":"Effective observation on treating myasthenia gravis with the Buzhong Yiqi decoction plus hormone","author":"Zu L. H.","year":"2015","journal-title":"Clinical Journal of Chinese Medicine"},{"key":"e_1_2_8_34_2","first-page":"19044","article-title":"Effects of combined traditional Chinese medicine with immunosuppressive agents for patients with myasthenia gravis","volume":"8","author":"Qi G.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_35_2","first-page":"153","article-title":"Theory and management of traditional Chinese Medicine in myasthenia gravis patients","volume":"26","author":"Yang Y.","year":"2004","journal-title":"Hebei Journal of Traditional Chinese Medicine"},{"key":"e_1_2_8_36_2","first-page":"161","article-title":"Progress in treatment of myasthenia gravis with traditional Chinese Medicine","volume":"27","author":"Mo L. B.","year":"2014","journal-title":"Guangxi Journal of Traditional Chinese Medicine"},{"key":"e_1_2_8_37_2","first-page":"1558","article-title":"Research progress of Chinese Medicine treatment of myasthenia gravis crisis","volume":"22","author":"Qin W. S.","year":"2016","journal-title":"Medical Recapitulate"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_39_2","unstructured":"2011 Higgins JPT Green Se. Cochrane Handbook for Systematic Reviews of Interventions Version The Cochrane Collaboration http:\/\/www.cochrane-handbook.org."},{"key":"e_1_2_8_40_2","first-page":"1492","volume-title":"World Science and Technology-Modernization of Traditional Chinese Medicine and Materia Medica","author":"Lv A. K.","year":"2015"},{"key":"e_1_2_8_41_2","first-page":"121","article-title":"Efficacy and safety of Traditional Chinese Medicine and Western medicine in the treatment of myasthenia gravis: a meta-analysis","volume":"23","author":"Shuang X. P.","year":"2016","journal-title":"Research of Integrated Traditional Chinese and Western Medicine"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/6512572.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2017\/6512572.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2017\/6512572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:34:07Z","timestamp":1722908047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2017\/6512572"}},"subtitle":[],"editor":[{"given":"Gioacchino","family":"Calapai","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1155\/2017\/6512572"],"URL":"https:\/\/doi.org\/10.1155\/2017\/6512572","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6512572"}}