{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:22:54Z","timestamp":1790709774405,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T00:00:00Z","timestamp":1514678400000},"content-version":"vor","delay-in-days":364,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["N\/ST\/ZB\/16\/001\/1126"],"award-info":[{"award-number":["N\/ST\/ZB\/16\/001\/1126"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005297","name":"Uniwersytet Medyczny w Bialymstoku","doi-asserted-by":"publisher","award":["143-26591L"],"award-info":[{"award-number":["143-26591L"]}],"id":[{"id":"10.13039\/501100005297","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>This study compared the antioxidant status and major lipophilic antioxidants in patients with ataxia\u2010telangiectasia (AT) and Nijmegen breakage syndrome (NBS). Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and concentrations of coenzyme Q10 (CoQ10) and vitamins A and E were estimated in the plasma of 22 patients with AT, 12 children with NBS, and the healthy controls. In AT patients, TAS (median 261.7\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L) was statistically lower but TOS (496.8\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L) was significantly elevated in comparison with the healthy group (312.7\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L and 311.2\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L, resp.). Tocopherol (0.8\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) and CoQ10 (0.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) were reduced in AT patients versus control (1.4\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and 0.3\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, resp.). NBS patients also displayed statistically lower TAS levels (290.3\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L), while TOS (404.8\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L) was comparable to the controls. We found that in NBS patients retinol concentration (0.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) was highly elevated and CoQ10 (0.1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) was significantly lower in comparison with those in the healthy group. Our study confirms disturbances in redox homeostasis in AT and NBS patients and indicates a need for diagnosing oxidative stress in those cases as a potential disease biomarker. Decreased CoQ10 concentration found in NBS and AT indicates a need for possible supplementation.<\/jats:p>","DOI":"10.1155\/2017\/6745840","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T23:33:10Z","timestamp":1514763190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia\u2010Telangiectasia and Nijmegen Breakage 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