{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:00Z","timestamp":1740164580105,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that &lt;1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.<jats:italic>Patient Findings<\/jats:italic>. A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto\u2019s thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy.<jats:italic>Summary<\/jats:italic>. Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms.<jats:italic>Conclusion<\/jats:italic>. Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index &lt; 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve.<\/jats:p>","DOI":"10.1155\/2017\/6749801","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T23:31:52Z","timestamp":1514244712000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Mantle Cell Lymphoma in the Thyroid: A Rare Presentation"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9506-8408","authenticated-orcid":true,"given":"Uzma Mohammad","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Division of Endocrinology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarika N.","family":"Rao","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, MedStar Washington Hospital Center, 110 Irving St NW, Suite 2A-72, Washington, DC 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