{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:02:20Z","timestamp":1769166140777,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Pulmonary endothelium dysfunction is a key characteristic of ARDS. The aim of this study was to investigate endothelium-derived markers, such as angiopoietin-2 (Ang-2) and endothelial cell-specific molecule-1 (endocan), at the vascular and alveolar compartments as outcome predictors in ARDS. Fifty-three consecutive ARDS patients were studied. The primary outcome was 28-day mortality. Secondary endpoints were days of unassisted ventilation and days with organ failure other than ARDS, during the 28-day study period. Nonsurvivors presented higher lung injury scores and epithelial lining fluid (ELF) Ang-2 levels compared to survivors, with no significant differences in plasma Ang-2, endocan, and protein C concentrations between the two groups. In logistic regression analysis, ELF Ang-2 levels\u2009&gt;\u2009705\u2009pg\/ml were the only independent variable for 28-day mortality among the previous four. Plasma endocan values\u2009&gt;\u200913\u2009ng\/pg were the only parameter predictive against days of unassisted ventilation during the 28-day study period. Finally, lung injury score\u2009&gt;\u20092.25 and ELF Ang-2 levels\u2009&gt;\u2009705\u2009pg\/ml were associated with increased number of days with organ failure, other than ARDS. Our findings suggest that Ang-2 levels are increased in the alveolar compartment of ARDS patients, and this may be associated both with increased mortality and organ failure besides lung.<\/jats:p>","DOI":"10.1155\/2017\/6758721","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T17:01:34Z","timestamp":1504026094000},"page":"1-6","source":"Crossref","is-referenced-by-count":21,"title":["Angiopoietin-2 Levels as Predictors of Outcome in Mechanically Ventilated Patients with Acute Respiratory Distress Syndrome"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4395-0471","authenticated-orcid":true,"given":"Iraklis","family":"Tsangaris","sequence":"first","affiliation":[{"name":"Second Department of Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argirios","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology & Blood Bank Unit, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Vrigkou","sequence":"additional","affiliation":[{"name":"Second Department of Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-4482","authenticated-orcid":true,"given":"Petros","family":"Kopterides","sequence":"additional","affiliation":[{"name":"Second Department of Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, 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