{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:56:45Z","timestamp":1772751405069,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Provincial 333 Project","award":["BRA2013280"],"award-info":[{"award-number":["BRA2013280"]}]},{"name":"Jiangsu Provincial 333 Project","award":["RC2011059"],"award-info":[{"award-number":["RC2011059"]}]},{"name":"Jiangsu Provincial 333 Project","award":["BK20171505"],"award-info":[{"award-number":["BK20171505"]}]},{"name":"Medical ZhongDianRenCai Project","award":["BRA2013280"],"award-info":[{"award-number":["BRA2013280"]}]},{"name":"Medical ZhongDianRenCai Project","award":["RC2011059"],"award-info":[{"award-number":["RC2011059"]}]},{"name":"Medical ZhongDianRenCai Project","award":["BK20171505"],"award-info":[{"award-number":["BK20171505"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BRA2013280"],"award-info":[{"award-number":["BRA2013280"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["RC2011059"],"award-info":[{"award-number":["RC2011059"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171505"],"award-info":[{"award-number":["BK20171505"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Long noncoding RNA (lncRNA) phosphatase and tensin homolog pseudogene 1 (PTENP1) is significantly downregulated in gastric cancer (GC), playing critical roles in GC progression. However, the association between PTENP1 genetic variants and GC risk has not yet been reported. Using TaqMan technology, three lncRNA PTENP1 tag single nucleotide polymorphisms (tagSNPs) (rs7853346 C&gt;G, rs865005 C&gt;T, and rs10971638 G&gt;A) were genotyped in 768 GC patients and 768 cancer-free controls in a Chinese population. We found that subjects with rs7853346 G allele had a remarkably decreased risk of GC, compared with those carrying C allele (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:math> in an additive model, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.033<\/mml:mn><\/mml:math> after Bonferroni\u2019s correction). The further stratified analyses showed that the link between variant genotypes of rs7853346 and decreased GC risk was more obvious in older subjects (\u226560 years), nonsmokers, nondrinkers, and subjects without family history of GC. We also found that relative PTENP1 mRNA expression levels were higher in rs7853346 CG\/GG genotype carriers than those with common genotype in both GC and normal tissues (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Besides, bioinformatics analyses revealed that rs7853346 may change the local folding structure and alter the target microRNAs (miRNAs) of PTENP1. In conclusion, our results suggested that lncRNA PTENP1 polymorphism rs7853346 may predict GC susceptibility.<\/jats:p>","DOI":"10.1155\/2017\/6807452","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T17:02:03Z","timestamp":1503939723000},"page":"1-8","source":"Crossref","is-referenced-by-count":18,"title":["Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1568-3601","authenticated-orcid":true,"given":"Yugang","family":"Ge","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-7081","authenticated-orcid":true,"given":"Yu","family":"He","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-649X","authenticated-orcid":true,"given":"Mingkun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-5930","authenticated-orcid":true,"given":"Dakui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8503-1743","authenticated-orcid":true,"given":"Xiangkun","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weizhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diancai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-2239","authenticated-orcid":true,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3752-8728","authenticated-orcid":true,"given":"Jundong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, 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