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IL-6 secretion is related with the activation of the ABCC transporters. This study assesses ABCC1\u20134 gene expression changes and proinflammatory cytokine (IL-6, IL-8) release in human bronchial epithelial cells (BEAS-2B) exposed to PM<jats:sub>2.5<\/jats:sub> organic extract, budesonide (BUD, used to control inflammation in asthmatic patients), and a cotreatment (Co-T: PM<jats:sub>2.5<\/jats:sub> and BUD). A real-time PCR assay shows that ABCC1 was upregulated in BEAS-2B exposed after 6 and 7\u2009hr to PM<jats:sub>2.5<\/jats:sub> extract or BUD but downregulated after 6\u2009hr of the Co-T. ABCC3 was downregulated after 6\u2009hr of BUD and upregulated after 6\u2009hr of the Co-T exposures. ABCC4 was upregulated after 5\u2009hr of PM<jats:sub>2.5<\/jats:sub> extract, BUD, and the Co-T exposures. The cytokine assay revealed an increase in IL-6 release by BEAS-2B exposed after 5\u2009hr to PM<jats:sub>2.5<\/jats:sub> extract, BUD, and the Co-T. At 7\u2009hr, the Co-T decreases IL-6 release and IL-8 at 6\u2009hr. In conclusion, the cotreatment showed an opposite effect on exposed BEAS-2B as compared with BUD. The results suggest an interference of the BUD therapeutic potential by PM<jats:sub>2.5<\/jats:sub>.<\/jats:p>","DOI":"10.1155\/2017\/6827194","type":"journal-article","created":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T17:05:17Z","timestamp":1502903117000},"page":"1-12","source":"Crossref","is-referenced-by-count":6,"title":["Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM<sub>2.5<\/sub>, Budesonide, and Cotreated Exposures"],"prefix":"10.1155","volume":"2017","author":[{"given":"Jarline","family":"Encarnaci\u00f3n-Medina","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of Puerto Rico, Medical Science Campus, San Juan, PR, USA"},{"name":"Center for Environmental and Toxicological Research, San Juan, PR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa I.","family":"Rodr\u00edguez-Cotto","sequence":"additional","affiliation":[{"name":"Center for Environmental and Toxicological Research, San Juan, PR, USA"},{"name":"School of Medicine, University of Puerto Rico, San Juan, PR, USA"},{"name":"Institute of Biomedical and Forensic Sciences Research of Puerto Rico Inc. 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