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However, the cellular and molecular mechanisms of those therapies are still needed to be illustrated. In this study, we characterized the cardioprotective effects of Hongjingtian Injection (HJT), an extensively used botanical drug for treating coronary heart disease. The H\/R\u2010induced profound elevation of oxidative stress was suppressed by HJT. HJT also attenuates oxidative injury by promoting cell viability, intracellular ATP contents, and mitochondrial oxygen consumption. Validation experiments indicated that HJT inhibited H\/R\u2010induced apoptosis and regulated the expression of apoptosis\u2010associated proteins Bcl\u20102 and cleaved caspase3. Interestingly, HJT significantly regulated the expression of autophagy\u2010related proteins LC3, Beclin, and mTOR as well as ERK and AKT. We provide evidence that the mechanism involves activation of AKT\/Beclin\u20101, AKT, and ERK\/mTOR pathway in cardiomyocyte autophagy. Histological and physiological evaluation revealed that HJT significantly decreased the infarct area of the heart, improved cardiac function, and increased the expression of LC3B in a rat model of coronary occlusion. From the obtained data, we proposed that HJT diminished myocardial oxidative damage through regulating the balance of autophagy and apoptosis and reducing oxidative stress.<\/jats:p>","DOI":"10.1155\/2017\/6965739","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T21:02:46Z","timestamp":1500498166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hongjingtian Injection Attenuates Myocardial Oxidative Damage via Promoting Autophagy and Inhibiting Apoptosis"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-7386","authenticated-orcid":false,"given":"Shujing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-1879","authenticated-orcid":false,"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-6857","authenticated-orcid":false,"given":"Guanwei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuwen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongbao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3676-9183","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-5316","authenticated-orcid":false,"given":"Xiaoping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1211"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2014.11.231"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.11.051"},{"key":"e_1_2_10_4_2","first-page":"139","article-title":"Clinical observation of sofren injection in the treatment of angina pectoris","volume":"54","author":"Qi M.","year":"2016","journal-title":"China Modern Doctor"},{"key":"e_1_2_10_5_2","first-page":"119","article-title":"Studies on chemical constituents from Rhodiola wallichiana","volume":"22","author":"Na Z.","year":"2016","journal-title":"Journal of Tianjin Medical University"},{"key":"e_1_2_10_6_2","first-page":"1001","article-title":"The effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption of dogs","volume":"30","author":"Zhang Z. 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