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We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to<jats:italic> Clostridium septicum<\/jats:italic> 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.<\/jats:p>","DOI":"10.1155\/2017\/6971027","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T17:00:48Z","timestamp":1506445248000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-3495","authenticated-orcid":true,"given":"Abdullateef","family":"Abdulkareem","sequence":"first","affiliation":[{"name":"Department of Medicine, Reading Hospital, West Reading, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan S.","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Reading Hospital, West Reading, PA, USA"},{"name":"Department of Anesthesiology, Mayo Clinic 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