{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:34:41Z","timestamp":1789227281983,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373097"],"award-info":[{"award-number":["81373097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["16110311400"],"award-info":[{"award-number":["16110311400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Science and Technology in Henan Province","award":["81373097"],"award-info":[{"award-number":["81373097"]}]},{"name":"Major Project of Science and Technology in Henan Province","award":["16110311400"],"award-info":[{"award-number":["16110311400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>IL23\/Th17 axis acts as an inflammatory pathway in gastric carcinogenesis. MicroRNA- (miRNA-) binding site single-nucleotide polymorphisms (SNPs) of inflammatory genes may alter gastric cancer (GC) susceptibility. In this study, four miRNA binding site SNPs (rs3748067 of <jats:italic>IL17A<\/jats:italic>, rs887796, rs1468488 of <jats:italic>IL17RA<\/jats:italic>, and rs10889677 of <jats:italic>IL23R<\/jats:italic>) were genotyped from 500 patients and 500 controls. Unconditional logistic regression analyses and multifactor dimensionality reduction software were used to evaluate the relationships of SNPs with GC and gene-environment interactions, respectively. Quantitative real-time PCR, Western blot analysis, and luciferase report gene assay were applied for function verification. We found that CT (OR<jats:sub>adj<\/jats:sub>\u2009=\u20090.59; 95% CI: 0.44\u20130.79), CT + TT (OR<jats:sub>adj<\/jats:sub>\u2009=\u20090.58; 95% CI: 0.43\u20130.77) genotypes, and T allele (OR<jats:sub>adj<\/jats:sub>\u2009=\u20090.77; 95% CI: 0.47\u20130.80) of rs3748067 reduced GC risk; the rs10889677 CC genotype (OR<jats:sub>adj<\/jats:sub>\u2009=\u20092.22; 95% CI: 1.27\u20133.87) and C allele (OR<jats:sub>adj<\/jats:sub>\u2009=\u20091.24; 95% CI: 1.02\u20131.52) increased GC risk. A meaningful interaction among ever smoked, family history of GC, and rs3748068 could intensify GC risk by 2.25-fold. Functional tests demonstrated the inhibitory effect of miR-10a-3p on <jats:italic>IL17A<\/jats:italic> expression in SGC-7901 cells. These results suggested that miRNA binding site SNPs within IL23\/Th17 inflammatory pathway genes and their interactions with environmental factors could be associated with GC risk.<\/jats:p>","DOI":"10.1155\/2017\/6974696","type":"journal-article","created":{"date-parts":[[2017,10,8]],"date-time":"2017-10-08T17:01:59Z","timestamp":1507482119000},"page":"1-11","source":"Crossref","is-referenced-by-count":13,"title":["Associations of Functional MicroRNA Binding Site Polymorphisms in IL23\/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk"],"prefix":"10.1155","volume":"2017","author":[{"given":"Kaiyan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China"},{"name":"Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan, 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