{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T06:17:58Z","timestamp":1766902678051,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Williams\u2013Beuren syndrome (WBS) is a rare multisystem disorder caused by a hemizygous deletion of the elastin gene on chromosome 7q11.23. WBS patients have characteristic skeletal features and dental anomalies accompanied by mental retardation, a friendly outgoing personality, and mild to moderate intellectual disability or learning problems. In this case report, we present the combined orthodontic and surgical treatment of a WBS patient with an isolated cleft palate through a long\u2010term follow\u2010up from the age of 5 to 24 years. During the period of active treatment, comprehensive orthodontic treatment combined with maxillary anterior segmental distraction osteogenesis and prosthetic treatment using dental implants were effective in dramatically improving the patient\u2019s malocclusion. The patient\u2019s mental abilities and the cooperation shown by the patient and her family were crucial for the success of this complex and long\u2010term treatment course.<\/jats:p>","DOI":"10.1155\/2017\/7019045","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T17:04:07Z","timestamp":1499187847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Orthodontic Treatment and Maxillary Anterior Segmental Distraction Osteogenesis of a Subject with Williams\u2013Beuren Syndrome and Isolated Cleft Palate: A Long\u2010Term Follow\u2010Up from the Age of 5 to 24 Years"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9806-7163","authenticated-orcid":false,"given":"Tetsutaro","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shirota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Adel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugo","family":"Haga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Nagahama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misato","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Furuhata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Kamatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koutaro","family":"Maki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjm031"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30266"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(64)90154-7"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1893"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80272-5"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.95103"},{"key":"e_1_2_7_7_2","first-page":"262","article-title":"Williams syndrome--oral presentation of 45 cases.","volume":"16","author":"Hertzberg J.","year":"1994","journal-title":"Pediatric dentistry"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0746.110071"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.03.019"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/2176-9451.20.1.097-107.oar"},{"volume-title":"Variability of the cranial and dental phenotype in Williams syndrome. 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