{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:42:34Z","timestamp":1790847754885,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate clinically activated retinal astrocytes and M\u00fcller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). <jats:italic>Methods<\/jats:italic>. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM\u2212) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT). <jats:italic>Results<\/jats:italic>. In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34\u00a0dB, ARAM\u2212: 11.9\u00a0dB; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM\u2212 (RNFL superior: ARAM+ 74.2\u00a0\u03bcm, ARAM\u2212 77.5\u00a0\u03bcm; RNFL temporal: ARAM+ 46.8\u00a0\u03bcm, ARAM\u2212 53.0\u00a0\u03bcm, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>; and RNFL inferior: ARAM+ 63.2\u00a0\u03bcm, ARAM\u2212 73.1\u00a0\u03bcm, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM\u2212 ([ARAM\u2212 (11.13\u00a0dB)]\u00a0\u2212\u00a0[ARAM+ (9.56\u00a0dB)\u00a0=\u00a01.57\u00a0dB; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.25<\/mml:mn><\/mml:math>). The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>), corresponding lower peripapillary RNFL thickness (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>), and lower RNFL temporal quadrant thickness (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), but not with greater age (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.45<\/mml:mn><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG.<\/jats:p>","DOI":"10.1155\/2017\/7043752","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T17:04:09Z","timestamp":1498583049000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients"],"prefix":"10.1155","volume":"2017","author":[{"given":"Christoph","family":"N\u00fctzi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Glaucoma Service, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sch\u00f6tzau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Glaucoma Service, University of Basel, Basel, Switzerland"},{"name":"Center for Biomedical Statistics, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-4309","authenticated-orcid":true,"given":"Matthias C.","family":"Grieshaber","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Glaucoma Service, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.10.053"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5099"},{"issue":"4","key":"4","first-page":"257","volume":"2","year":"1993","journal-title":"Journal of Glaucoma"},{"key":"5","first-page":"1","volume":"1","year":"2006","journal-title":"South East European Journal of Ophthalmology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31802d045a"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.06.003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.07.001"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20207"},{"issue":"4","key":"10","first-page":"1088","volume":"43","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"11","first-page":"69","volume":"313","year":"2009","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Belge d'Ophtalmologie"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.07.003"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/1878-5085-4-14"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.10.008"},{"key":"15","year":"2016"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(96)00005-3"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)90024-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.12.044"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1281857"},{"key":"20","first-page":"225","volume-title":"Retinal glia","year":"2009"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0195"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3129\/i08-056"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.10.001"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/7043752.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/7043752.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2017\/7043752.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T17:05:24Z","timestamp":1498583124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/joph\/2017\/7043752\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":23,"alternative-id":["7043752","7043752"],"URL":"https:\/\/doi.org\/10.1155\/2017\/7043752","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}