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Low circulating concentrations of MBL have been associated with increased risk of infection and poor neurologic outcome in neonates. On the other hand, an excessive and uncontrolled inflammatory response by the neonatal intestine after the exposure to luminal bacteria, leading to an increased production of MBL, may be involved in the onset of necrotizing enterocolitis. The purpose of the present review is to summarize the current knowledge about genetic and biologic characteristics of MBL and its role in the susceptibility to infections and to ischemia-reperfusion related tissue injuries to better explore its clinical relevance during the perinatal period and the possible future therapeutic applications.<\/jats:p>","DOI":"10.1155\/2017\/7045630","type":"journal-article","created":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T21:04:07Z","timestamp":1485464647000},"page":"1-11","source":"Crossref","is-referenced-by-count":47,"title":["Mannose-Binding Lectin: Biologic Characteristics and Role in the Susceptibility to Infections and Ischemia-Reperfusion Related Injury in Critically Ill Neonates"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-6557","authenticated-orcid":true,"given":"Cinzia","family":"Auriti","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Neonatology, Bambino Ges\u00f9 Children\u2019s Hospital (IRCCS), Piazza S. 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