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The inflammatory response directed against <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>HP<\/jats:italic>) is believed to be one of the main triggers of the appearance of gastric lesions and their progression to gastric cancer (GC). Epstein-Barr virus (EBV) has been found responsible for about 10% of all GCs, but the inflammatory response has not been studied in GC patients with evidence of high levels of EBV reactivation. <jats:italic>Objective<\/jats:italic>. To determine the relationship between inflammation and antibodies against EBV reactivation antigens, <jats:italic>HP<\/jats:italic>, and the bacterium virulence factor CagA in patients with GC. <jats:italic>Methods<\/jats:italic>. 127 GC patients, 46 gastritis patients, and 197 healthy subjects were studied. IL-1<jats:italic>\u03b2<\/jats:italic>, IL-6, IL-8, IL-10, TNF-<jats:italic>\u03b1<\/jats:italic>, TGF-<jats:italic>\u03b2<\/jats:italic>, MCP-1, and IFN-<jats:italic>\u03b3<\/jats:italic> levels were measured in serum or plasma and compared against the antibody titers of VCA-IgG, <jats:italic>HP<\/jats:italic>, and the <jats:italic>HP<\/jats:italic> virulence factor CagA. Statistical associations were estimated. <jats:italic>Results<\/jats:italic>. Significant ORs and positive trends were found between VCA-IgG and IFN-<jats:italic>\u03b3<\/jats:italic>, specifically for patients with GC of intestinal type (OR: 6.4, 95% C.I. 1.2\u201335.4) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.044<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. We confirmed a positive association between a marker of EBV reactivation and intestinal gastric cancer and present evidence of a correlation with elevated serum levels of IFN-<jats:italic>\u03b3<\/jats:italic>, but not with the other cytokines.<\/jats:p>","DOI":"10.1155\/2017\/7069242","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T18:31:20Z","timestamp":1510684280000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Elevated Levels of Interferon-<i>\u03b3<\/i> Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer"],"prefix":"10.1155","volume":"2017","author":[{"given":"Mar\u00eda G.","family":"C\u00e1rdenas-Mondrag\u00f3n","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatr\u00eda, Dr. Silvestre Frenk Freund, CMN Siglo-XXI, Instituto Mexicano del 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