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Topical administration of ripasudil decreases intraocular pressure (IOP) by increasing conventional outflow through the trabeculae to Schlemm\u2019s canal, which is different from existing agents that suppress aqueous humor production or promote uveoscleral outflow. In this study, we demonstrated that ripasudil significantly lowered IOP in combined regimens with other glaucoma therapeutic agents in rabbits and monkeys. Ripasudil showed additional effects on maximum IOP lowering or prolonged the duration of IOP-lowering effects with combined administration of timolol, nipradilol, brimonidine, brinzolamide, latanoprost, latanoprost\/timolol fixed combination, and dorzolamide\/timolol fixed combination. These results indicate that facilitation of conventional outflow by ripasudil provides additive IOP-lowering effect with other classes of antiglaucoma agents. Ripasudil is expected to have substantial utility in combined regimens with existing agents for glaucoma treatment.<\/jats:p>","DOI":"10.1155\/2017\/7079645","type":"journal-article","created":{"date-parts":[[2017,4,30]],"date-time":"2017-04-30T17:01:17Z","timestamp":1493571677000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1170-4404","authenticated-orcid":true,"given":"Yoshio","family":"Kaneko","sequence":"first","affiliation":[{"name":"Tokyo New Drug Research Laboratories, Kowa Co. Ltd., 2-17-43 Noguchicho, Higashimurayama, Tokyo 189-0022, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohta","sequence":"additional","affiliation":[{"name":"Tokyo New Drug Research Laboratories, Kowa Co. 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