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Recently, the crystal structure of transmissible gastroenteritis virus (TGEV) PL1 has been solved, which was similar to that of SARS-CoV<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi mathvariant=\"normal\">P<\/mml:mi><mml:mi mathvariant=\"normal\">L<\/mml:mi><mml:msup><mml:mrow><mml:mn mathvariant=\"normal\">2<\/mml:mn><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">p<\/mml:mi><mml:mi mathvariant=\"normal\">r<\/mml:mi><mml:mi mathvariant=\"normal\">o<\/mml:mi><\/mml:mrow><\/mml:msup><\/mml:math>, which may antagonize host innate immunity. However, very little is known about whether TGEV PL1 can antagonize host innate immune response. Here, we presented evidence that TGEV PL1 encoded by the replicase gene could suppress the IFN-<jats:italic>\u03b2<\/jats:italic>expression and inhibit the nuclear translocation of interferon regulatory factor 3 (IRF3). The ability to antagonize IFN-<jats:italic>\u03b2<\/jats:italic>production was dependent on the intact catalytic activity of PL1. Furthermore, TGEV PL1 exerted deubiquitinase (DUB) activity which strongly inhibited the retinoic acid-induced gene I- (RIG-1-) and stimulator of interferon gene- (STING-) dependent IFN expression. Our data collectively suggest that TGEV PL1 can inhibit the IFN-<jats:italic>\u03b2<\/jats:italic>expression and interfere with RIG-1- and STING-mediated signaling through a viral DUB activity. Our study has yielded strong evidence for the TGEV PL1 mechanisms that counteract the host innate immunity.<\/jats:p>","DOI":"10.1155\/2017\/7089091","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T23:40:14Z","timestamp":1508802014000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-<i>\u03b2<\/i>through Its Deubiquitinase Activity"],"prefix":"10.1155","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4237-1195","authenticated-orcid":true,"given":"Xiaoliang","family":"Hu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key 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