{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:08:48Z","timestamp":1792080528962,"version":"4.4.0"},"reference-count":100,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect relationship. These drawbacks limited the application of cyclodestructive procedures almost exclusively to refractory glaucoma. High-intensity focused ultrasound (HIFU), proposed in the early 1980s and later abandoned because of the complexity and side effects of the procedure, was recently reconsidered in a new approach to destroy the ciliary body. Ultrasound circular cyclocoagulation (UC<jats:sup>3<\/jats:sup>), by using miniaturized transducers embedded in a dedicated circular-shaped device, permits to selectively treat the ciliary body in a one-step, computer-assisted, and non-operator-dependent procedure. UC<jats:sup>3<\/jats:sup> shows a high level of safety along with a predictable and sustained IOP reduction in patients with refractory glaucoma. Because of this, the indication of UC<jats:sup>3<\/jats:sup> was recently extended also to na\u00efve-to-surgery patients, thus reconsidering the role and timing of ciliary body ablation in the surgical management of glaucoma. This article provides a review of the most used cycloablative techniques with particular attention to UC<jats:sup>3<\/jats:sup>, summarizing the current knowledge about this procedure and future possible developments.<\/jats:p>","DOI":"10.1155\/2017\/7136275","type":"journal-article","created":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T17:00:36Z","timestamp":1492966836000},"page":"1-14","source":"Crossref","is-referenced-by-count":26,"title":["High-Intensity Focused Ultrasound Circular Cyclocoagulation in Glaucoma: A Step Forward for Cyclodestruction?"],"prefix":"10.1155","volume":"2017","author":[{"given":"Rodolfo","family":"Mastropasqua","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital, London EC1V 2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-052X","authenticated-orcid":true,"given":"Vincenzo","family":"Fasanella","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department 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