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The purpose of this research was to elucidate the effect of BSS on ease of parturition using a systems\u2010level in silico analytic approach. Research results show that BSS is highly connected to the parturition related pathways, biological processes, and organs. There were numerous interactions between most compounds of BSS and multiple target genes, and this was confirmed using herb\u2010compound\u2010target network, target\u2010pathway network, and gene ontology analysis. Furthermore, the mRNA expression of relevant target genes of BSS was elevated significantly in related organ tissues, such as those of the uterus, placenta, fetus, hypothalamus, and pituitary gland. This study used a network analytical approach to demonstrate that Bulsu\u2010san (BSS) is closely related to the parturition related pathways, biological processes, and organs. It is meaningful that this systems\u2010level network analysis result strengthens the basis of clinical applications of BSS on ease of parturition.<\/jats:p>","DOI":"10.1155\/2017\/7236436","type":"journal-article","created":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T23:31:27Z","timestamp":1509319887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systems Pharmacological Approach to the Effect of <i>Bulsu-san<\/i> Promoting Parturition"],"prefix":"10.1155","volume":"2017","author":[{"given":"Su Yeon","family":"Suh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-2114","authenticated-orcid":false,"given":"Won G.","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,29]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"67","article-title":"The prescriptions of enriching blood and nourishing vital essence (Fill yin blood prescription)","volume":"20","author":"Kim S.","year":"2007","journal-title":"Journal of Korean Medical Classics"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.01.033"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.14369\/skmc.2016.29.1.017"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4268\/cjcmm20111325"},{"key":"e_1_2_8_5_2","article-title":"Establishment and optimization of acute blood stasis rat model","volume":"12","author":"Li W.","year":"2011","journal-title":"Chinese Pharmacological Bulletin"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.051"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051670"},{"key":"e_1_2_8_8_2","article-title":"Effects of radix angelicae sinensis and rhizoma chuanxiong on mouse uterine contractions in vitro","volume":"2","author":"Li W.","year":"2010","journal-title":"Journal of Nanjing University of Traditional Chinese Medicine"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1530\/reprod\/121.4.493"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.107841"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13297.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-31"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13066964"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.303"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.09.051"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16022913"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci9800211"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.02.004"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.12.1507"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.06.001"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.019"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp980230o"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.06.008"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037608"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj161"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp101"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq675"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080747"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep32400"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-010-9252-z"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.011"},{"key":"e_1_2_8_32_2","first-page":"870","article-title":"Ischemic stroke treated with ligusticum chuanxiong","volume":"105","author":"Chen K. 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