{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:55:02Z","timestamp":1783464902075,"version":"3.55.0"},"reference-count":168,"publisher":"Wiley","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Aneurysms are characterized by structural deterioration of the vascular wall leading to progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often remain clinically silent, the morbidity and mortality associated with aneurysm expansion and rupture are considerable. Over 13,000 deaths annually in the United States are attributable to aortic aneurysm rupture with less than 1 in 3 persons with aortic aneurysm rupture surviving to surgical intervention. Environmental and epidemiologic risk factors including smoking, male gender, hypertension, older age, dyslipidemia, atherosclerosis, and family history are highly associated with abdominal aortic aneurysms, while heritable genetic mutations are commonly associated with aneurysms of the thoracic aorta. Similar to other forms of cardiovascular disease, family history, genetic variation, and heritable mutations modify the risk of aortic aneurysm formation and provide mechanistic insight into the pathogenesis of human aortic aneurysms. This review will examine the relationship between heritable genetic and epigenetic influences on thoracic and abdominal aortic aneurysm formation and rupture.<\/jats:p>","DOI":"10.1155\/2017\/7268521","type":"journal-article","created":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T21:02:02Z","timestamp":1483390922000},"page":"1-12","source":"Crossref","is-referenced-by-count":38,"title":["Genetic and Epigenetic Regulation of Aortic Aneurysms"],"prefix":"10.1155","volume":"2017","author":[{"given":"Ha Won","family":"Kim","sequence":"first","affiliation":[{"name":"Vascular Biology Center, Augusta University, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-8895","authenticated-orcid":true,"given":"Brian K.","family":"Stansfield","sequence":"additional","affiliation":[{"name":"Vascular Biology Center, Augusta University, Augusta, GA, USA"},{"name":"Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcibr0905244"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1383.030"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.115.306538"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.04.098"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0703"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1038\/ng.934"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10249"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/ng1511"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.141"},{"issue":"1","key":"45","first-page":"112","volume":"47","year":"1990","journal-title":"American Journal of Human Genetics"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq356"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.00974"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.02.020"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm201"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1038\/ng1721"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.6"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.04.007"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307130"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.11.015"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248161"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1038\/ng.744"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh336"},{"issue":"11","key":"27","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1681\/ASN.V7112483","volume":"7","year":"1996","journal-title":"Journal of the American Society of Nephrology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200205000-00002"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.09.022"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006320"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/415168a"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw082"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X09355667"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2005.12.001"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6345"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.12.004"},{"issue":"24","key":"61","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1093\/hmg\/ddm258","volume":"16","year":"2007","journal-title":"Human Molecular Genetics"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01909-5"},{"issue":"5","key":"81","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ajhg.2011.10.002","volume":"89","year":"2011","journal-title":"The American Journal of Human Genetics"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000165"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01486.x"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.034"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1038\/nature10145"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.05.004"},{"key":"114","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000347"},{"key":"115","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000004793"},{"issue":"3","key":"116","first-page":"421","volume":"34","year":"2006","journal-title":"Clinical Hemorheology and Microcirculation"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.114.304016"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1038\/nm1099"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160511259"},{"key":"159","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003441"},{"key":"162","doi-asserted-by":"publisher","DOI":"10.1172\/jci61598"},{"key":"163","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.253740"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200608167"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7166-z"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055695"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30069"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537340"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.019"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.958066"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1172\/jci83778"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34050"},{"key":"21","volume-title":"Thoracic aortic aneurysms and aortic dissections","year":"1993"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.07.070"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199209243271303"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.13"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.149252"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2010.09.004"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1177\/0003319709354752"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.041"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/ng.622"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32809"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.18.2113"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.02.004"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-11"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00194.2010"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111213200"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1172\/jci200215334"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199706123362413"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)70153-2"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.81.3.448"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90017-9"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-11-0638"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.07.022"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1038\/ng1116"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.113.300675"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192152"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192149"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2012.07.005"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1172\/jci38136"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.10.053"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20102610795"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.04.038"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050374"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-7061(99)00152-1"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107001473"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0836"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1308\/003588414X13946184901560"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.1.b16"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2272(200010)19:3<202::aid-gepi2>3.0.co;2-q"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00626.x"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90252-A"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.06.002"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv635"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds502"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.28.11.752"},{"issue":"3","key":"93","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jvs.2007.03.055","volume":"46","year":"2007","journal-title":"Journal of Vascular Surgery"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0152"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1007\/s004679900260"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1038\/377695a0"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150544.00016.69"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.06.007"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.7.2228"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.305115"},{"key":"104","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28487"},{"key":"105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01777.x"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00357"},{"key":"107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105806"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-291x(02)02420-8"},{"issue":"12","key":"109","first-page":"1258","volume":"30","year":"2014","journal-title":"Chinese Journal of Cellular and Molecular Immunology"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m403738200"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m210369200"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.024513"},{"key":"113","doi-asserted-by":"publisher","DOI":"10.1159\/000110041"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.107563"},{"key":"118","doi-asserted-by":"publisher","DOI":"10.1038\/srep17966"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.10.022"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.02.019"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.001"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.5.433"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00132"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.03.003"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0310OC"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808699105"},{"key":"127","doi-asserted-by":"publisher","DOI":"10.1161\/circgenetics.116.001506"},{"key":"128","doi-asserted-by":"publisher","DOI":"10.4161\/15592294.2014.969637"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0001"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32021"},{"key":"131","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.6.16196"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2006.05.015"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2004.11.045"},{"key":"136","first-page":"202","volume":"84","year":"1983","journal-title":"Recent Results in Cancer Research"},{"key":"137","doi-asserted-by":"publisher","DOI":"10.1126\/science.6844925"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-015-0118-4"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x02vm418oa"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.895296"},{"key":"141","first-page":"141","volume":"72","year":"1998","journal-title":"Advances in Cancer Research"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.1.181"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg234"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.74.2.129"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.13.5759"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.3275\/7981"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02429-06"},{"key":"150","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2012.0300"},{"key":"151","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03243.x"},{"key":"152","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00037"},{"key":"153","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt268"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1506fje"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn603"},{"key":"156","doi-asserted-by":"publisher","DOI":"10.1159\/000339303"},{"key":"157","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-5-25"},{"key":"158","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.112.000745"},{"key":"160","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2010.172"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.2174\/15701611113119990015"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.04.016"},{"key":"165","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9802"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.255737"},{"key":"167","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1038\/ncomms6214","volume":"5","year":"2014","journal-title":"Nature Communications"},{"key":"168","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.113.303134"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/7268521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/7268521.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2017\/7268521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T12:15:33Z","timestamp":1658319333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bmri\/2017\/7268521\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":168,"alternative-id":["7268521","7268521"],"URL":"https:\/\/doi.org\/10.1155\/2017\/7268521","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}